Universität zu Köln

Treuer, H., Hoevels, M., Luyken, K., Gierich, A., Hellerbach, A., Lachtermann, B., Visser-Vandewalle, V., Ruge, M. and Wirths, J. (2015). Voxel-based dose calculation in radiocolloid therapy of cystic craniopharyngiomas. Phys. Med. Biol., 60 (3). S. 1159 - 1171. BRISTOL: IOP PUBLISHING LTD. ISSN 1361-6560

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Abstract

Very high doses are administered in radiocolloid therapy of cystic craniopharyngiomas. However individual dose planning is not common yet mainly due to insufficient image resolution. Our aim was to investigate whether currently available high-resolution image data can be used for voxel-based dose calculation for short-ranged beta-emitters (P-32,Y-90,Re-186) and to assess the achievable accuracy. We developed a convolution algorithm based on voxelized dose activity distributions and dose-spread kernels. Results for targets with 5-40 mm diameter were compared with high-resolution Monte Carlo calculations in spherical phantoms. Voxel size was 0.35 mm. Homogeneous volume and surface activity distributions were used. Dose-volume histograms of targets and shell structures were compared and gamma index (dose tolerance 5%, distance to agreement 0.35 mm) was calculated for dose profiles along the principal axes. For volumetric activity distributions 89.3% +/- 11.9% of all points passed the gamma test (mean gamma 0.53 +/- 0.16). For surface distributions 33.6% +/- 14.8% of all points passed the gamma test (mean gamma 2.01 +/- 0.60). The shift of curves in dose-volume histograms was -1.7 Gy +/- 7.6 Gy (-4.4 Gy +/- 24.1 Gy for Re-186) in volumetric distributions and 46.3% +/- 32.8% in surface distributions. The results show that individual dose planning for radiocolloid therapy of cystic craniopharyngiomas based on high-resolution voxelized image data is feasible and yields highly accurate results for volumetric activity distributions and reasonable dose estimates for surface distributions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Treuer, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoevels, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Luyken, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gierich, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellerbach, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lachtermann, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruge, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirths, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-407722
DOI:	10.1088/0031-9155/60/3/1159
Journal or Publication Title:	Phys. Med. Biol.
Volume:	60
Number:	3
Page Range:	S. 1159 - 1171
Date:	2015
Publisher:	IOP PUBLISHING LTD
Place of Publication:	BRISTOL
ISSN:	1361-6560
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NONUNIFORM ACTIVITY DISTRIBUTIONS; BRAIN-TUMORS; POINT-KERNEL; S VALUES; P-32; MANAGEMENT; DOSIMETRY; IRRADIATION; PHOSPHATE; Y-90 Multiple languages Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40772