Hoffmann, C., Hentrich, M., Gillor, D., Behrens, G., Jensen, B., Stoehr, A., Esser, S., van Lunzen, J., Krznaric, I., Mueller, M., Oette, M., Hensel, M., Thoden, J., Faetkenheuer, G. and Wyen, C. (2015). Hodgkin lymphoma is as common as non-Hodgkin lymphoma in HIV-positive patients with sustained viral suppression and limited immune deficiency: a prospective cohort study. HIV Med., 16 (4). S. 261 - 265. HOBOKEN: WILEY-BLACKWELL. ISSN 1468-1293

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Abstract

ObjectivesThe incidence of HIV-related non-Hodgkin lymphoma (NHL) but not that of Hodgkin lymphoma (HL) has been declining. The aim of the study was to compare HIV-infected patients with NHL and HL with respect to antiretroviral therapy (ART) exposure at the time of lymphoma diagnosis. MethodsHIV-infected patients with NHL and HL included in a prospective multicentre cohort study since January 2005 were compared with respect to ART exposure and viral load at the time of lymphoma diagnosis. ResultsAs of 31 December 2012, data for 329 patients with NHL and 86 patients with HL from 31 participating centres were available. Patients with HL were more likely to be on ART (73.5% vs. 39.1%, respectively; P<0.001) and more frequently had a viral load below the detection limit (57.3% vs. 27.9%, respectively; P<0.001) than patients with NHL. The proportion of patients with HL was 8.0% in ART-naive patients, 34.8% in patients with current HIV RNA <50 HIV-1 RNA copies/mL, and 50.0% in patients with both HIV RNA <50 copies/mL for >12 months and a CD4 cell count of >200 cells/L. Of note, 45.8% of all patients with NHL were not currently on ART and had a CD4 count of <350 cells/L. ConclusionsThis prospective cohort study shows that HL was as common as NHL in patients with sustained viral suppression and limited immune deficiency. In contrast to NHL, the majority of patients with HL were on effective ART, suggesting that ART provides insufficient protection from developing HL. The high proportion of untreated patients with NHL suggests missed opportunities for earlier initiation of ART.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hoffmann, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hentrich, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gillor, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Behrens, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jensen, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoehr, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Esser, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Lunzen, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krznaric, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oette, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hensel, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thoden, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faetkenheuer, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wyen, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-408597
DOI: 10.1111/hiv.12200
Journal or Publication Title: HIV Med.
Volume: 16
Number: 4
Page Range: S. 261 - 265
Date: 2015
Publisher: WILEY-BLACKWELL
Place of Publication: HOBOKEN
ISSN: 1468-1293
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
COMBINATION ANTIRETROVIRAL THERAPY; INFECTED PATIENTS; UNITED-STATES; RISK-FACTORS; CANCER-RISK; IMMUNODEFICIENCY; AIDS; ERAMultiple languages
Infectious DiseasesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/40859

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