Universität zu Köln

Demmert, Martin ORCID: 0000-0001-7552-3736, Schaper, Anne, Pagel, Julia, Gebauer, Corinna, Emeis, Michael, Heitmann, Friedhelm, Kribs, Angela, Siegel, Jens, Mueller, Dirk, Keller-Wackerbauer, Annette, Gerleve, Hubert, Wieg, Christian, Herting, Egbert, Gopel, Wolfgang and Haertel, Christoph (2015). FUT 2 polymorphism and outcome in very-low-birth-weight infants. Pediatr. Res., 77 (4). S. 586 - 591. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1530-0447

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Abstract

BACKGROUND: To determine whether the secretor gene fucosyltransferase (FUT)2 polymorphism G428A is predictive for adverse outcomes in a large cohort of very-low-birth weight (VLBW) infants. METHODS: We prospectively enrolled 2,406 VLBW infants from the population-based multicenter cohort of the German Neonatal network cohort (2009-2011). The secretor genotype (rs601338) was assessed from DNA samples extracted from buccal swabs. Primary study outcomes were clinical sepsis, blood-culture confirmed sepsis, intracerebral hemorrhage (ICH), necrotizing enterocolitis (NEC) or focal intestinal perforation requiring surgery, and death. RESULTS: Based on the assumption of a recessive genetic model, AA individuals had a higher incidence of ICH (AA: 19.0% vs. GG/AG: 14.9%, P = 0.04) which was not significant in the additive genetic model (muitivariable logistic regression analysis; allele carriers: 365 cases, 1,685 controls; OR: 1.2; 95% CI: 0.99-1.4; P = 0.06). Other outcomes were not influenced by FUT2 genotype in either genetic model. CONCLUSION: This large-scale multicenter study did not confirm previously reported associations between FUT2 genotype and adverse outcomes in preterm infants.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Demmert, Martin UNSPECIFIED orcid.org/0000-0001-7552-3736 UNSPECIFIED Schaper, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Pagel, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Gebauer, Corinna UNSPECIFIED UNSPECIFIED UNSPECIFIED Emeis, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Heitmann, Friedhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Kribs, Angela UNSPECIFIED UNSPECIFIED UNSPECIFIED Siegel, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Keller-Wackerbauer, Annette UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerleve, Hubert UNSPECIFIED UNSPECIFIED UNSPECIFIED Wieg, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Herting, Egbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Gopel, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Haertel, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-408642
DOI:	10.1038/pr.2015.1
Journal or Publication Title:	Pediatr. Res.
Volume:	77
Number:	4
Page Range:	S. 586 - 591
Date:	2015
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	NEW YORK
ISSN:	1530-0447
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NONSENSE MUTATION; SECRETOR STATUS; RISK; SUSCEPTIBILITY; ASSOCIATION; INFECTIONS; DISEASE; ASTHMA Multiple languages Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40864