Universität zu Köln

Galldiks, N. and Langen, K. -J. (2015). Applications of PET imaging of neurological tumors with radiolabeled amino acids. Q. J. Nucl. Med. Mol. Imag., 59 (1). S. 70 - 83. TURIN: EDIZIONI MINERVA MEDICA. ISSN 1827-1936

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Abstract

Routine diagnostics and treatment monitoring of brain tumors is usually based on contrast-enhanced magnetic resonance imaging (MRI). However, the capacity of structural MRI to differentiate neoplastic tissue from non-specific treatment changes may be limited especially after therapeutic interventions such as neurosurgical resection, radio- and chemotherapy. Metabolic imaging using PET may provide relevant additional information on tumor metabolism, which allows for more accurate diagnostics especially in clinically equivocal situations. In contrast to the widely used F-18-2-fluoro-2-deoxy-D-glucose, which exhibits a poor tumor-to-background contrast within the brain, amino acid tracers provide high sensitivity to detect primary tumors, recurrent or residual gliomas, including most low-grade gliomas. The method improves targeting of biopsy and provides additional information of tumor extent, which is helpful for planning neurosurgery and radiotherapy. In the further course of the disease, amino acid positron-emission tomography (PET) allows a sensitive monitoring of treatment response, the early detection of tumor recurrence, and an improved differentiation of tumor recurrence from treatment-related changes. In the past, the method had only limited availability due to the use of radiopharmaceuticals with a short half-life. In recent years, however, novel amino acid tracers labeled with positron emitters with a longer half-life have been developed and clinically validated which allow a more efficient and cost-effective application. These developments and the well-documented diagnostic performance of PET using radiolabeled amino acids suggest that its application continues to spread and that the method may be available as a routine diagnostic technique for certain indications in the near future.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Galldiks, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, K. -J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-410327
Journal or Publication Title:	Q. J. Nucl. Med. Mol. Imag.
Volume:	59
Number:	1
Page Range:	S. 70 - 83
Date:	2015
Publisher:	EDIZIONI MINERVA MEDICA
Place of Publication:	TURIN
ISSN:	1827-1936
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; LOW-GRADE GLIOMA; COST-EFFECTIVENESS ANALYSIS; RECURRENT MALIGNANT GLIOMA; CONTRAST-ENHANCING GLIOMAS; CHILDHOOD BRAIN-TUMORS; F-18 FET-PET; C-11-METHIONINE PET; O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET; RADIATION NECROSIS Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41032