Universität zu Köln

Bender, Stephan, Banaschewski, Tobias ORCID: 0000-0003-4595-1144, Roessner, Veit, Klein, Christoph, Rietschel, Marcella, Feige, Bernd ORCID: 0000-0002-9436-1258, Brandeis, Daniel and Laucht, Manfred (2015). Variability of single trial brain activation predicts fluctuations in reaction time. Biol. Psychol., 106. S. 50 - 61. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1873-6246

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Abstract

Brain activation stability is crucial to understanding attention lapses. EEG methods could provide excellent markers to assess neuronal response variability with respect to temporal (intertrial coherence) and spatial variability (topographic consistency) as well as variations in activation intensity (low frequency variability of single trial global field power). We calculated intertrial coherence, topographic consistency and low frequency amplitude variability during target P300 in a continuous performance test in 263 15-year-olds from a cohort with psychosocial and biological risk factors. Topographic consistency and low frequency amplitude variability predicted reaction time fluctuations (RTSD) in a linear model. Higher RTSD was only associated with higher psychosocial adversity in the presence of the homozygous 6R-10R dopamine transporter haplotype. We propose that topographic variability of single trial P300 reflects noise as well as variability in evoked cortical activation patterns. Dopaminergic neuromodulation interacted with environmental and biological risk factors to predict behavioural reaction time variability. (C) 2015 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bender, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Banaschewski, Tobias UNSPECIFIED orcid.org/0000-0003-4595-1144 UNSPECIFIED Roessner, Veit UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Rietschel, Marcella UNSPECIFIED UNSPECIFIED UNSPECIFIED Feige, Bernd UNSPECIFIED orcid.org/0000-0002-9436-1258 UNSPECIFIED Brandeis, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Laucht, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-410950
DOI:	10.1016/j.biopsycho.2015.01.013
Journal or Publication Title:	Biol. Psychol.
Volume:	106
Page Range:	S. 50 - 61
Date:	2015
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1873-6246
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEFICIT/HYPERACTIVITY DISORDER SYMPTOMS; ATTENTION; CHILDREN; ADHD; HYPERACTIVITY; DEFICIT; SCHIZOPHRENIA; COMPONENTS; GENOTYPE; WORKING Multiple languages Psychology, Biological; Behavioral Sciences; Psychology; Psychology, Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41095