Universität zu Köln

Schennach, Rebecca, Riedel, Michael, Obermeier, Michael, Spellmann, Ilja, Musil, Richard ORCID: 0000-0002-0792-8413, Jaeger, Markus, Schmauss, Max, Laux, Gerd, Pfeiffer, Herbert, Naber, Dieter, Schmidt, Lutz G., Gaebel, Wolfgang, Klosterkoetter, Joachim, Heuser, Isabella, Maier, Wolfgang, Lemke, Matthias R., Ruether, Eckart, Klingberg, Stefan ORCID: 0000-0001-8081-7181, Gastpar, Markus and Moeller, Hans-Juergen (2015). What are residual symptoms in schizophrenia spectrum disorder? Clinical description and 1-year persistence within a naturalistic trial. Eur. Arch. Psych. Clin. Neurosci., 265 (2). S. 107 - 117. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-8491

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Abstract

The aim of this study was to evaluate residual symptoms in patients achieving remission according to the consensus criteria and to analyze their potential influence on the patient's outcome one year after discharge. In total, 399 patients suffering from a schizophrenia spectrum disorder were evaluated within a naturalistic study. Remission status was examined using the consensus criteria. Residual symptoms were defined as any symptom present at the time-point of remission following analogous analyses performed in depressed patients. Therefore, a PANSS item with a symptom severity of > 1 (= at least borderline mentally ill) was defined to be a residual symptom. Remitters with and without residual symptoms were compared regarding psychopathology, functioning and side effects. In total, 236 patients (59 %) were remitters at discharge with 94 % of them suffering from at least one residual symptom. The most common residual symptoms were blunted affect (49 %), conceptual disorganization (42 %) and social withdrawal (40 %). A significant association was found between the presence of residual symptoms and the severity of side effects (p < 0.0001) and functioning (p = 0.0003) at discharge as well as between residual symptoms and the risk of relapse and chance of remission one year after discharge. Residual symptoms were highly prevalent in remitted schizophrenia inpatients following the suggested definition. Most residual symptoms were persistent baseline symptoms suggesting an ongoing illness severity. Also, the necessity to re-evaluate the consensus criteria questioning the status of remission in these patients is also pointed out.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schennach, Rebecca UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Obermeier, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Spellmann, Ilja UNSPECIFIED UNSPECIFIED UNSPECIFIED Musil, Richard UNSPECIFIED orcid.org/0000-0002-0792-8413 UNSPECIFIED Jaeger, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmauss, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Laux, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfeiffer, Herbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Naber, Dieter UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Lutz G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaebel, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkoetter, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Heuser, Isabella UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemke, Matthias R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruether, Eckart UNSPECIFIED UNSPECIFIED UNSPECIFIED Klingberg, Stefan UNSPECIFIED orcid.org/0000-0001-8081-7181 UNSPECIFIED Gastpar, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Moeller, Hans-Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-411156
DOI:	10.1007/s00406-014-0528-2
Journal or Publication Title:	Eur. Arch. Psych. Clin. Neurosci.
Volume:	265
Number:	2
Page Range:	S. 107 - 117
Date:	2015
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-8491
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; NEGATIVE SYMPTOMS; FOLLOW-UP; 1ST-EPISODE SCHIZOPHRENIA; DEPRESSIVE SYMPTOMS; REMISSION; OUTCOMES; RELAPSE; INSIGHT; CARE Multiple languages Clinical Neurology; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41115