Universität zu Köln

Kuhn, J., Hardenacke, K., Lenartz, D., Gruendler, T., Ullsperger, M., Bartsch, C., Mai, J. K., Zilles, K., Bauer, A., Matusch, A., Schulz, R-J, Noreik, M., Buehrle, C. P., Maintz, D., Woopen, C., Haeussermann, P., Hellmich, M., Klosterkotter, J., Wiltfang, J., Maarouf, M., Freund, H-J and Sturm, V. (2015). Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer's dementia. Mol. Psychiatr., 20 (3). S. 353 - 361. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5578

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Abstract

Cholinergic neurons of the medial forebrain are considered important contributors to brain plasticity and neuromodulation. A reduction of cholinergic innervation can lead to pathophysiological changes of neurotransmission and is observed in Alzheimer's disease. Here we report on six patients with mild to moderate Alzheimer's disease (AD) treated with bilateral low-frequency deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM). During a four-week double-blind sham-controlled phase and a subsequent 11-month follow-up open label period, clinical outcome was assessed by neuropsychological examination using the Alzheimer's Disease Assessment Scale-cognitive subscale as the primary outcome measure. Electroencephalography and [F-18]-fluoro-desoxyglucose positron emission tomography were, besides others, secondary endpoints. On the basis of stable or improved primary outcome parameters twelve months after surgery, four of the six patients were considered responders. No severe or nontransitional side effects related to the stimulation were observed. Taking into account all limitations of a pilot study, we conclude that DBS of the NBM is both technically feasible and well tolerated.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kuhn, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hardenacke, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lenartz, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruendler, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ullsperger, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bartsch, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mai, J. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zilles, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Matusch, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz, R-J UNSPECIFIED UNSPECIFIED UNSPECIFIED Noreik, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Buehrle, C. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Woopen, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haeussermann, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkotter, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiltfang, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maarouf, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Freund, H-J UNSPECIFIED UNSPECIFIED UNSPECIFIED Sturm, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-411880
DOI:	10.1038/mp.2014.32
Journal or Publication Title:	Mol. Psychiatr.
Volume:	20
Number:	3
Page Range:	S. 353 - 361
Date:	2015
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-5578
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SENILE-DEMENTIA; CHOLINERGIC INNERVATION; COGNITIVE IMPAIRMENT; PARKINSONS-DISEASE; MEMORY ENHANCEMENT; FOREBRAIN; EXPRESSION; CORTEX; NEURONS; PATIENT Multiple languages Biochemistry & Molecular Biology; Neurosciences; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41188