Jansen, Christian, Reiberger, Thomas ORCID: 0000-0002-4590-3583, Huang, Jia, Eischeid, Hannah, Schierwagen, Robert ORCID: 0000-0002-2195-3666, Mandorfer, Mattias ORCID: 0000-0003-2330-0017, Anadol, Evrim, Schwabl, Philipp ORCID: 0000-0002-7183-8076, Schwarze-Zander, Carolynne, Warnecke-Eberz, Ute, Strassburg, Christian P., Rockstroh, Juergen K., Peck-Radosavljevic, Markus, Odenthal, Margarete and Trebicka, Jonel ORCID: 0000-0002-7028-3881 (2015). Circulating MiRNA-122 Levels Are Associated with Hepatic Necroinflammation and Portal Hypertension in HIV/HCV Coinfection. PLoS One, 10 (2). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background Introduction of combined antiretroviral therapy (cART) has improved survival of HIV infected individuals, while the relative contribution of liver-related mortality increased. Especially in HIV/HCV-coinfected patients hepatic fibrosis and portal hypertension represent the main causes of liver-related morbidity and mortality. Circulating miRNA-122 levels are elevated in HIV patients and have been shown to correlate with severity of liver injury. However, the association of miRNA-122 levels and hepatic fibrosis and portal hypertension remains to be explored in HIV/HCV coinfection. Methods From a total of 74 (31% female) patients with HIV/HCV coinfection were included. Serum levels of miRNA-122 were analyzed by quantitative polymerase chain reaction (PCR) and normalized to SV-40 spike-in RNA. Hepatic venous pressure gradient (HVPG) was measured in 52 (70%) patients and the fibrosis stage was determined in 63 (85%) patients using transient elastography. Results The levels of circulating miRNA-122 were increased in HIV/HCV coinfected patients and significantly correlated with the alanine aminotransferase (ALT) (r(s) = 0.438; p<0.001) and aspartate transaminase AST values (r(s) = 0.336; p = 0.003), but not with fibrosis stage (p = n.s.). Interestingly, miRNA-122 levels showed an inverse correlation with hepatic venous pressure gradient (HVPG) (r(s) = -0.302; p = 0.03). Conclusion Elevated miRNA-122 levels are associated with liver injury, and with low HVPG. Though, miRNA-122 levels are not suitable to predict the degree of fibrosis, they might function as indicators for portal hypertension in HIV/HCV coinfected patients.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Jansen, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reiberger, ThomasUNSPECIFIEDorcid.org/0000-0002-4590-3583UNSPECIFIED
Huang, JiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eischeid, HannahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schierwagen, RobertUNSPECIFIEDorcid.org/0000-0002-2195-3666UNSPECIFIED
Mandorfer, MattiasUNSPECIFIEDorcid.org/0000-0003-2330-0017UNSPECIFIED
Anadol, EvrimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwabl, PhilippUNSPECIFIEDorcid.org/0000-0002-7183-8076UNSPECIFIED
Schwarze-Zander, CarolynneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Warnecke-Eberz, UteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strassburg, Christian P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rockstroh, Juergen K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peck-Radosavljevic, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Odenthal, MargareteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trebicka, JonelUNSPECIFIEDorcid.org/0000-0002-7028-3881UNSPECIFIED
URN: urn:nbn:de:hbz:38-412699
DOI: 10.1371/journal.pone.0116768
Journal or Publication Title: PLoS One
Volume: 10
Number: 2
Date: 2015
Publisher: PUBLIC LIBRARY SCIENCE
Place of Publication: SAN FRANCISCO
ISSN: 1932-6203
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SUSTAINED VIROLOGICAL RESPONSE; CO-INFECTED PATIENTS; HEPATOCELLULAR-CARCINOMA; LIVER-DISEASE; VIRUS; HIV; CIRRHOSIS; FIBROSIS; THERAPY; DECOMPENSATIONMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/41269

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