Universität zu Köln

Zimmer, Philipp, Mierau, Andreas ORCID: 0000-0002-6305-3260, Bloch, Wilhelm, Strueder, Heiko K., Huelsduenker, Thorben, Schenk, Alexander, Fiebig, Leonie, Baumann, Freek T., Hahn, Moritz, Reinart, Nina, Hallek, Michael and Elter, Thomas (2015). Post-chemotherapy cognitive impairment in patients with B-cell non-Hodgkin lymphoma: a first comprehensive approach to determine cognitive impairments after treatment with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone or rituximab and bendamustine. Leuk. Lymphoma, 56 (2). S. 347 - 353. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1029-2403

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Abstract

To assess the effects of chemoimmunotherapy on post-chemotherapy cognitive impairments (PCCI) in patients with B-cell non-Hodgkin lymphoma (NHL), we used objective and subjective measures of cognitive functions in combination with serum parameters and neuroelectric recordings. Self-perceived status of cognition, fatigue and emotional functioning were reduced in patients (n = 30) compared to healthy controls (n = 10). Cognitive performance was impaired in patients with NHL compared to controls and a norm sample (n = 1179). PCCI was more severe in patients treated with rituximab and bendamustine (BR) than in patients who received R in combination with CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) polychemotherapy (R-CHOP). Individual alpha peak frequency and serum brain-derived neurotrophic factor (BDNF) levels in patients with NHL correlated with accuracy in the objective cognition test. Higher serum interleukin-6 (IL-6) concentrations were associated with higher fatigue levels. Patients with NHL and especially those who were treated with BR were affected by PCCI. BDNF and IL-6 might be involved in the pathogenesis of PCCI and fatigue.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zimmer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Mierau, Andreas UNSPECIFIED orcid.org/0000-0002-6305-3260 UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Strueder, Heiko K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Huelsduenker, Thorben UNSPECIFIED UNSPECIFIED UNSPECIFIED Schenk, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Fiebig, Leonie UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumann, Freek T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hahn, Moritz UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinart, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Elter, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-413294
DOI:	10.3109/10428194.2014.915546
Journal or Publication Title:	Leuk. Lymphoma
Volume:	56
Number:	2
Page Range:	S. 347 - 353
Date:	2015
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1029-2403
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BREAST-CANCER; MEMORY PERFORMANCE; CHEMOTHERAPY; ALPHA; SYMPTOMS; FATIGUE; WOMEN Multiple languages Oncology; Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41329