Westphal, Philipp, Mauch, Cornelia, Florin, Alexandra, Czerwitzki, Jacqueline, Olligschlaeger, Nina, Wodtke, Claudia, Schuele, Roland, Buettner, Reinhard and Friedrichs, Nicolaus (2015). Enhanced FHL2 and TGF-beta 1 Expression Is Associated With Invasive Growth and Poor Survival in Malignant Melanomas. Am. J. Clin. Pathol., 143 (2). S. 248 - 257. CHICAGO: AMER SOC CLINICAL PATHOLOGY. ISSN 1943-7722
Full text not available from this repository.Abstract
Objectives: This study examines the expression and the role offour-and-a-half LIM domains protein 2 (FHL2) and transforming growth factor beta 1 (TGF-beta 1) in human malignant melanoma. It is determined whether both proteins influence melanoma survival time. Methods: We analyzed the immunohistochemical staining intensities of FHL2 and TGF-beta 1 in normal skin and in 50 malignant melanomas with different mutation status (BRAF-V600E, NRAS codon 61 mutation, and wild type). Survival data were available for 45 cases. Results: In melanocytes of nonneoplastic human skin, FHL2 expression was absent. In contrast, 38 (76%) of 50 melanomas showed strong cytoplasmic and partly nuclear FHL2 expression. At the invasion front, cytoplasmic TGF-beta 1 staining was observed in 32 (64%) of 50 melanomas, and a correlation of FHL2 and TGF-beta 1 staining intensities was detectable. In follow-up analyses, enhanced FHL2 and TGF-beta 1 staining intensities in the tumor invasion front were associated with poor survival. Conclusions: Enhanced FHL2 and TGF-beta 1 expression is correlated with poor survival in human malignant melanoma. Protumorigenic effects of autocrine TGF-beta 1 secretion might be exerted by induction of FHL2 expression in melanoma cells. Since melanomas treated with targeted therapies often do not show sufficient response rates, inhibition of FHL2 and/or TGF-beta 1 might be a promising therapeutic approach.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-413562 | ||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1309/AJCPXEC6CIT2TXAF | ||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Am. J. Clin. Pathol. | ||||||||||||||||||||||||||||||||||||||||
Volume: | 143 | ||||||||||||||||||||||||||||||||||||||||
Number: | 2 | ||||||||||||||||||||||||||||||||||||||||
Page Range: | S. 248 - 257 | ||||||||||||||||||||||||||||||||||||||||
Date: | 2015 | ||||||||||||||||||||||||||||||||||||||||
Publisher: | AMER SOC CLINICAL PATHOLOGY | ||||||||||||||||||||||||||||||||||||||||
Place of Publication: | CHICAGO | ||||||||||||||||||||||||||||||||||||||||
ISSN: | 1943-7722 | ||||||||||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/41356 |
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