Universität zu Köln

Rueger, Maria Adele and Schroeter, Michael (2015). In vivo imaging of endogenous neural stem cells in the adult brain. World J. Stem Cells, 7 (1). S. 75 - 84. PLEASANTON: BAISHIDENG PUBLISHING GROUP INC. ISSN 1948-0210

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Abstract

The discovery of endogenous neural stem cells (eNSCs) in the adult mammalian brain with their ability to self-renew and differentiate into functional neurons, astrocytes and oligodendrocytes has raised the hope for novel therapies of neurological diseases. Experimentally, those eNSCs can be mobilized in vivo, enhancing regeneration and accelerating functional recovery after, e.g., focal cerebral ischemia, thus constituting a most promising approach in stem cell research. In order to translate those current experimental approaches into a clinical setting in the future, non-invasive imaging methods are required to monitor eNSC activation in a longitudinal and intra-individual manner. As yet, imaging protocols to assess eNSC mobilization non-invasively in the live brain remain scarce, but considerable progress has been made in this field in recent years. This review summarizes and discusses the current imaging modalities suitable to monitor eNSCs in individual experimental animals over time, including optical imaging, magnetic resonance tomography and-spectroscopy, as well as positron emission tomography (PET). Special emphasis is put on the potential of each imaging method for a possible clinical translation, and on the specificity of the signal obtained. PET-imaging with the radiotracer 3'-deoxy3'-[F-18]fluoro-L-thymidine in particular constitutes a modality with excellent potential for clinical translation but low specificity; however, concomitant imaging of neuroinflammation is feasible and increases its specificity. The non-invasive imaging strategies presented here allow for the exploitation of novel treatment strategies based upon the regenerative potential of eNSCs, and will help to facilitate a translation into the clinical setting.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rueger, Maria Adele UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeter, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-414347
DOI:	10.4252/wjsc.v7.i1.75
Journal or Publication Title:	World J. Stem Cells
Volume:	7
Number:	1
Page Range:	S. 75 - 84
Date:	2015
Publisher:	BAISHIDENG PUBLISHING GROUP INC
Place of Publication:	PLEASANTON
ISSN:	1948-0210
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FOCAL CEREBRAL-ISCHEMIA; SUBVENTRICULAR ZONE; PROGENITOR CELLS; NERVOUS-SYSTEM; HIPPOCAMPAL NEUROGENESIS; MAMMALIAN FOREBRAIN; DENTATE GYRUS; PROLIFERATION; MIGRATION; NEURONS Multiple languages Cell & Tissue Engineering; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41434