Universität zu Köln

Khodakarami, Amirabbas, Saez, Isabel, Mels, Johanna and Vilchez, David ORCID: 0000-0002-0801-0743 (2015). Mediation of organismal aging and somatic proteostasis by the germline. Front. Mol. Biosci., 2. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2296-889X

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Abstract

Experimental interventions that reduce reproduction cause an extension in lifespan. In invertebrates, such as Caenorhabditis elegans, the aging of the soma is regulated by signals from the germline. Indeed, ablation of germ cells significantly extends lifespan. Notably, germline-deficient animals exhibit heightened resistance to proteotoxic stress. This phenotype correlates with increased potential of intracellular clearance mechanisms such as the proteasome and autophagy in somatic tissues. Here we review the molecular mechanisms by which signals from the germline regulate lifespan in C. elegans with special emphasis on clearance mechanisms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Khodakarami, Amirabbas UNSPECIFIED UNSPECIFIED UNSPECIFIED Saez, Isabel UNSPECIFIED UNSPECIFIED UNSPECIFIED Mels, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Vilchez, David UNSPECIFIED orcid.org/0000-0002-0801-0743 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-414381
DOI:	10.3389/fmolb.2015.00003
Journal or Publication Title:	Front. Mol. Biosci.
Volume:	2
Date:	2015
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	2296-889X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41438