Universität zu Köln

Jacobs, Heidi I. L., Dillen, Kim N. H., Risius, Okka, Goereci, Yasemin, Onur, Oezguer A., Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Kukolja, Juraj ORCID: 0000-0003-1569-3287 (2015). Consolidation in older adults depends upon competition between resting-state networks. Front. Aging Neurosci., 6. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1663-4365

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Abstract

Memory encoding and retrieval problems are inherent to aging. To date, however, the effect of aging upon the neural correlates of forming memory traces remains poorly understood. Resting-state fMRI connectivity can be used to investigate initial consolidation. We compared within and between network connectivity differences between healthy young and older participants before encoding, after encoding and before retrieval by means of resting-state fMRI. Alterations over time in the between-network connectivity analyses correlated with retrieval performance, whereas within-network connectivity did not: a higher level of negative coupling or competition between the default mode and the executive networks during the after encoding condition was associated with increased retrieval performance in the older adults, but not in the young group. Data suggest that the effective formation of memory traces depends on an age-dependent, dynamic reorganization of the interaction between multiple, large-scale functional networks. Our findings demonstrate that a cross-network based approach can further the understanding of the neural underpinnings of aging-associated memory decline.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jacobs, Heidi I. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dillen, Kim N. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Risius, Okka UNSPECIFIED UNSPECIFIED UNSPECIFIED Goereci, Yasemin UNSPECIFIED UNSPECIFIED UNSPECIFIED Onur, Oezguer A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Kukolja, Juraj UNSPECIFIED orcid.org/0000-0003-1569-3287 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-414735
DOI:	10.3389/fnagi.2014.00344
Journal or Publication Title:	Front. Aging Neurosci.
Volume:	6
Date:	2015
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1663-4365
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BRAIN ACTIVITY; PREFRONTAL CORTEX; DEFAULT NETWORK; LIFE-SPAN; MEMORY; HIPPOCAMPAL; CONNECTIVITY; FMRI; AGE; INTERACTIVITY Multiple languages Geriatrics & Gerontology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41473