Universität zu Köln

Doerr, Helmuth G., Bettendorf, Markus, Binder, Gerhard, Karges, Beate, Kneppo, Carolin, Schmidt, Heinrich, Voss, Egbert, Wabitsch, Martin and Doetsch, Joerg (2015). Levothyroxine Treatment of Euthyroid Children with Autoimmune Hashimoto Thyroiditis: Results of a Multicenter, Randomized, Controlled Trial. Horm. Res. Paediatr., 84 (4). S. 266 - 275. BASEL: KARGER. ISSN 1663-2826

Full text not available from this repository.

Abstract

Background: Levothyroxine (L-T4) treatment of euthyroid children with Hashimoto thyroiditis (HT) is a controversial issue. Patients and Methods: We conducted a prospective, randomized, controlled clinical trial. Out of 79 identified euthyroid patients, 59 started the study; 25 patients (21 female, 4 male; age: 11.8 +/- 2.3 years) received L-T4 at a mean dose of 1.6 mu g/kg (SD, 0.8) daily, and 34 (27 female, 7 male; age: 12.6 +/- 1.2 years) were not treated. Patients developing subclinical hypothyroidism during follow-up (n = 13) were treated with L-T4 and removed from the observation group. As the main outcome measures, thyroid gland volume (determined by ultrasound) as well as serum levels of TSH, free T4, and antibodies against thyroid peroxidase and thyroglobulin were assessed every 6 months for 36 months. Results: At the start, the mean thyroid volume (standard deviation score, SDS) was 2.5 in the treatment group and 1.6 in the observation group. There was a constant decline in mean thyroid volume (SDS) from 2.13 (month 12) to 1.12 (month 30) in the treated group, with a delta thyroid volume of -1.01 SDS. In the observation group, the mean delta thyroid volume increased to +0.27 SDS. The change of the delta thyroid volume was statistically significantly different between both groups during the 12- and 30-month time points (p < 0.05). L-T4 had no effect on thyroid function and serum thyroid antibodies. Conclusions: L-T4 treatment can decrease the thyroid volume in euthyroid children with HT, but the effect is limited to a definite time period. (C) 2015 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Doerr, Helmuth G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bettendorf, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Binder, Gerhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Karges, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED Kneppo, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Heinrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Voss, Egbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Wabitsch, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Doetsch, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-415592
DOI:	10.1159/000437140
Journal or Publication Title:	Horm. Res. Paediatr.
Volume:	84
Number:	4
Page Range:	S. 266 - 275
Date:	2015
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1663-2826
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NATURAL-HISTORY; FOLLOW-UP; ADOLESCENTS; CHILDHOOD; DISEASE; SCHOOLCHILDREN; GERMAN; VOLUME; SIZE; TIME Multiple languages Endocrinology & Metabolism; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41559