Universität zu Köln

Hauptmann, Christian, Stroebel, Armin, Williams, Mark, Patel, Nitesh, Wurzer, Hannes, von Stackelberg, Tatjana, Brinkmann, Uwe, Langguth, Berthold and Tass, Peter A. (2015). Acoustic Coordinated Reset Neuromodulation in a Real Life Patient Population with Chronic Tonal Tinnitus. Biomed Res. Int., 2015. LONDON: HINDAWI LTD. ISSN 2314-6141

Full text not available from this repository.

Abstract

Purpose. Primary tinnitus has a severe negative influence on the quality of life of a significant portion of the general population. Acoustic coordinated reset neuromodulation is designed to induce a long-lasting reduction of tinnitus symptoms. To test acoustic coordinated reset neuromodulation as a treatment for chronic, tonal tinnitus under real life conditions, an outpatient study RESET Real Life was commissioned by ANM GmbH. Herein we present the results of this study. Methods. In a prospective, open-label, nonrandomized, noncontrolled multicenter clinical study with 200 chronic tinnitus patients, tinnitus questionnaire TBF-12 and Global Clinical Improvement-Impression Scale (CGI-I7) are used to study the safety and efficacy of acoustic coordinated reset neuromodulation. 189 patients completed the last 12-month visit, 11 patients dropped out (8 because of nontreatment related reasons; 2 because tinnitus did not change; and 1 because tinnitus got louder). Results. Acoustic coordinated reset neuromodulation caused a statistically and clinically significant decrease in TBF-12 scores as well as in CGI-I7 after 12 months of therapy under real life conditions. There were no persistent adverse events reported that were related to the therapy. Conclusion. The field study RESET Real Life provides evidence for safety and efficacy of acoustic coordinated reset neuromodulation in a prospective, open-label, real life setting.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hauptmann, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Stroebel, Armin UNSPECIFIED UNSPECIFIED UNSPECIFIED Williams, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED Patel, Nitesh UNSPECIFIED UNSPECIFIED UNSPECIFIED Wurzer, Hannes UNSPECIFIED UNSPECIFIED UNSPECIFIED von Stackelberg, Tatjana UNSPECIFIED UNSPECIFIED UNSPECIFIED Brinkmann, Uwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Langguth, Berthold UNSPECIFIED UNSPECIFIED UNSPECIFIED Tass, Peter A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-415668
DOI:	10.1155/2015/569052
Journal or Publication Title:	Biomed Res. Int.
Volume:	2015
Date:	2015
Publisher:	HINDAWI LTD
Place of Publication:	LONDON
ISSN:	2314-6141
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BRAIN-STIMULATION; QUESTIONNAIRE; CONNECTIVITY; TRAUMA; SCALE; POWER Multiple languages Biotechnology & Applied Microbiology; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41566