Lista, Simone ORCID: 0000-0001-6804-7858, Molinuevo, Jose L., Cavedo, Enrica, Rami, Lorena, Amouyel, Philippe ORCID: 0000-0001-9088-234X, Teipel, Stefan J., Garaci, Francesco, Toschi, Nicola ORCID: 0000-0003-1929-5833, Habert, Marie-Odile, Blennow, Kaj, Zetterberg, Henrik, O'Bryant, Sid E., Johnson, Leigh, Galluzzi, Samantha ORCID: 0000-0001-9804-5669, Bokde, Arun L. W., Broich, Karl, Herholz, Karl, Bakardjian, Hovagim, Dubois, Bruno, Jessen, Frank, Carrillo, Maria C., Aisen, Paul S. and Hampel, Harald (2015). Evolving Evidence for the Value of Neuroimaging Methods and Biological Markers in Subjects Categorized with Subjective Cognitive Decline. J. Alzheimers Dis., 48. S. S171 - 21. AMSTERDAM: IOS PRESS. ISSN 1875-8908

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Abstract

There is evolving evidence that individuals categorized with subjective cognitive decline (SCD) are potentially at higher risk for developing objective and progressive cognitive impairment compared to cognitively healthy individuals without apparent subjective complaints. Interestingly, SCD, during advancing preclinical Alzheimer's disease (AD), may denote very early, subtle cognitive decline that cannot be identified using established standardized tests of cognitive performance. The substantial heterogeneity of existing SCD-related research data has led the Subjective Cognitive Decline Initiative (SCD-I) to accomplish an international consensus on the definition of a conceptual research framework on SCD in preclinical AD. In the area of biological markers, the cerebrospinal fluid signature of AD has been reported to be more prevalent in subjects with SCD compared to healthy controls; moreover, there is a pronounced atrophy, as demonstrated by magnetic resonance imaging, and an increased hypometabolism, as revealed by positron emission tomography, in characteristic brain regions affected by AD. In addition, SCD individuals carrying an apolipoprotein epsilon 4 allele are more likely to display AD-phenotypic alterations. The urgent requirement to detect and diagnose AD as early as possible has led to the critical examination of the diagnostic power of biological markers, neurophysiology, and neuroimaging methods for AD-related risk and clinical progression in individuals defined with SCD. Observational studies on the predictive value of SCD for developing AD may potentially be of practical value, and an evidence-based, validated, qualified, and fully operationalized concept may inform clinical diagnostic practice and guide earlier designs in future therapy trials.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Lista, SimoneUNSPECIFIEDorcid.org/0000-0001-6804-7858UNSPECIFIED
Molinuevo, Jose L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cavedo, EnricaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rami, LorenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amouyel, PhilippeUNSPECIFIEDorcid.org/0000-0001-9088-234XUNSPECIFIED
Teipel, Stefan J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garaci, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toschi, NicolaUNSPECIFIEDorcid.org/0000-0003-1929-5833UNSPECIFIED
Habert, Marie-OdileUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blennow, KajUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zetterberg, HenrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Bryant, Sid E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johnson, LeighUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Galluzzi, SamanthaUNSPECIFIEDorcid.org/0000-0001-9804-5669UNSPECIFIED
Bokde, Arun L. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Broich, KarlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herholz, KarlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bakardjian, HovagimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dubois, BrunoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carrillo, Maria C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aisen, Paul S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hampel, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-415896
DOI: 10.3233/JAD-150202
Journal or Publication Title: J. Alzheimers Dis.
Volume: 48
Page Range: S. S171 - 21
Date: 2015
Publisher: IOS PRESS
Place of Publication: AMSTERDAM
ISSN: 1875-8908
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BETA-AMYLOID 1-42; ALZHEIMERS ASSOCIATION WORKGROUPS; TRANSCRANIAL MAGNETIC STIMULATION; CEREBROSPINAL-FLUID BIOMARKERS; WHITE-MATTER HYPERINTENSITIES; HETEROGENEOUS BRAIN-TISSUE; GAUSSIAN WATER DIFFUSION; BLOOD-BASED BIOMARKERS; TEMPORAL-LOBE ATROPHY; PITTSBURGH-COMPOUND-BMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/41589

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