Universität zu Köln

Lademann, Hanne ORCID: 0000-0003-1320-163X, Gerber, Bernd, Olbertz, Dirk M., Darvin, Maxim E., Stauf, Leonie, Ueberholz, Kirsten, Heinrich, Verena, Lademann, Juergen and Briese, Volker (2015). Non-Invasive Spectroscopic Determination of the Antioxidative Status of Gravidae and Neonates. Skin Pharmacol. Physiol., 28 (4). S. 189 - 196. BASEL: KARGER. ISSN 1660-5535

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Abstract

Pregnancy and postpartum adaptation cause an increased formation of free radicals. This is associated with various perinatological diseases, e.g. necrotising enterocolitis. The human body has developed a protective system in the form of the antioxidative potential. The present study was the first to investigate the kinetics of the cutaneous antioxidative status in pregnant women and newborns using a non-invasive spectroscopic method. Eighteen pregnant women and their babies took part in the study. A light-emitting diode-based compact scanner system was used for quick non-invasive measurements of carotenoid antioxidants in human skin based on reflection spectroscopy. It could be shown that the antioxidative status of the expectant mothers significantly declined during labour (p < 0.001) and on day 1 after delivery (p < 0.01). Compared to the mothers, the newborns exhibited a significantly higher cutaneous carotenoid concentration on both day 1 (p < 0.01) and 5 (p < 0.01) after delivery. These results suggest that the oxidative stress due to postpartum adaptation is counteracted by an enhanced reservoir of carotenoid antioxidants in the subcutaneous fatty tissue. The peripartum cutaneous carotenoid level of mothers declines continuously, whereas term newborns show very high cutaneous antioxidant values. (C) 2015 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lademann, Hanne UNSPECIFIED orcid.org/0000-0003-1320-163X UNSPECIFIED Gerber, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Olbertz, Dirk M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Darvin, Maxim E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stauf, Leonie UNSPECIFIED UNSPECIFIED UNSPECIFIED Ueberholz, Kirsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinrich, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Lademann, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Briese, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-416510
DOI:	10.1159/000365520
Journal or Publication Title:	Skin Pharmacol. Physiol.
Volume:	28
Number:	4
Page Range:	S. 189 - 196
Date:	2015
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1660-5535
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN SKIN; OXIDATIVE STRESS; BETA-CAROTENE; FREE-RADICALS; IN-VIVO; HUMAN KERATINOCYTES; RAMAN-SPECTROSCOPY; HUMAN TISSUE; ANIMAL SKIN; VITAMIN-E Multiple languages Dermatology; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41651