Universität zu Köln

Siwek, Magdalena Elisabeth, Mueller, Ralf, Henseler, Christina, Trog, Astrid, Lundt, Andreas, Wormuth, Carola, Broich, Karl, Ehninger, Dan, Weiergraeber, Marco and Papazoglou, Anna (2015). Altered Theta Oscillations and Aberrant Cortical Excitatory Activity in the 5XFAD Model of Alzheimer's Disease. Neural. Plast., 2015. LONDON: HINDAWI LTD. ISSN 1687-5443

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Abstract

Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by impairment of memory function. The 5XFAD mouse model was analyzed and compared with wild-type (WT) controls for aberrant cortical excitability and hippocampal theta oscillations by using simultaneous video-electroencephalogram (EEG) monitoring. Seizure staging revealed that 5XFAD mice exhibited cortical hyperexcitability whereas controls did not. In addition, 5XFAD mice displayed a significant increase in hippocampal theta activity from the light to dark phase during nonmotor activity. We also observed a reduction in mean theta frequency in 5XFAD mice compared to controls that was again most prominent during nonmotor activity. Transcriptome analysis of hippocampal probes and subsequent qPCR validation revealed an upregulation of Plcd4 that might be indicative of enhanced muscarinic signalling. Our results suggest that 5XFAD mice exhibit altered cortical excitability, hippocampal dysrhythmicity, and potential changes in muscarinic signaling.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Siwek, Magdalena Elisabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Henseler, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Trog, Astrid UNSPECIFIED UNSPECIFIED UNSPECIFIED Lundt, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Wormuth, Carola UNSPECIFIED UNSPECIFIED UNSPECIFIED Broich, Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED Ehninger, Dan UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiergraeber, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Papazoglou, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-416824
DOI:	10.1155/2015/781731
Journal or Publication Title:	Neural. Plast.
Volume:	2015
Date:	2015
Publisher:	HINDAWI LTD
Place of Publication:	LONDON
ISSN:	1687-5443
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AMYLOID PRECURSOR PROTEIN; MILD COGNITIVE IMPAIRMENT; TRANSGENIC MICE; MEMORY DEFICITS; ENTORHINAL CORTEX; BETA-SECRETASE; MOUSE MODELS; NEURON LOSS; SEIZURES; EEG Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41682