Universität zu Köln

Ranjbar, Mahdy, Schneider, Toni, Brand, Carl, Grisanti, Salvatore, Lueke, Julia and Lueke, Matthias (2015). The Effect of Disease-Modifying Antirheumatic Drugs on Retinal Function in the Electrophysiological ex vivo Model of the Isolated Perfused Vertebrate Retina. Ophthalmic Res., 53 (3). S. 136 - 141. BASEL: KARGER. ISSN 1423-0259

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Abstract

Background: Disease-modifying antirheumatic drugs (DMARDs) have been suggested in the treatment of inflammatory ophthalmological diseases. The aim of the present study was to investigate the effects of these DMARDs on bovine retinal function. Methods: Bovine retina preparations were perfused with a standard solution. After recording stable electroretinograms the nutrient solution was substituted by a DMARD medium with varying concentrations of different drugs (etanercept and infliximab) for 30 min. Afterwards b-wave recovery was observed. Results: Significant decreases in the b-wave amplitude (p < 0.05) were found for etanercept 0.5 mg/ml (p = 0.0022). Infliximab 2 mg/ml (p = 0.1276) did not result in any statistically significant b-wave reduction. Conclusion: The presented data suggest that infliximab might have the better safety profile than etanercept. (C) 2015 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ranjbar, Mahdy UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Toni UNSPECIFIED UNSPECIFIED UNSPECIFIED Brand, Carl UNSPECIFIED UNSPECIFIED UNSPECIFIED Grisanti, Salvatore UNSPECIFIED UNSPECIFIED UNSPECIFIED Lueke, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Lueke, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-416833
DOI:	10.1159/000371731
Journal or Publication Title:	Ophthalmic Res.
Volume:	53
Number:	3
Page Range:	S. 136 - 141
Date:	2015
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1423-0259
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NECROSIS-FACTOR-ALPHA; INTRAVITREAL INFLIXIMAB; OCULAR SAFETY; TNF-ALPHA; RABBIT; ETANERCEPT; TOXICITY; ADHESION; UVEITIS Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41683