Universität zu Köln

Windschall, D., Muller, T., Becker, I. and Horneff, G. (2015). Safety and efficacy of etanercept in children with the JIA categories extended oligoarthritis, enthesitis-related arthritis and psoriasis arthritis. Clin. Rheumatol., 34 (1). S. 61 - 70. LONDON: SPRINGER LONDON LTD. ISSN 1434-9949

Full text not available from this repository.

Abstract

The approval of etanercept for the treatment of the juvenile idiopathic arthritis (JIA) categories extended oligoarthritis (ExtOA), enthesitis-related arthritis (ERA) and psoriasis arthritis (PsA) was recently added to the approval for the treatment of polyarticular-course JIA (PA). This study aims to evaluate the efficacy and safety of etanercept in a large number of patients with the additional JIA categories. The Biologika in der Kinderrheumatologie (BIKER) registry documents baseline demographics, clinical characteristics and disease activity parameters. Efficacy was determined using the PedACR 30/50/70 response criteria and the Juvenile Arthritis Disease Activity Score (JADAS)-10. Safety assessments were based on adverse events' reports. Until December 2012, a total of 1,678 JIA patients, incorporating 238 ERA, 315 ExtOA and 127 PsA patients were included. JADAS-10 demonstrated marked improvement compared to baseline after 3 to 24 months in ExtOA [16.1 +/- 7.6 (baseline), 5.1 +/- 5.2 (3 months), 3.0 +/- 3.5 (24 months)]; ERA (15.3 +/- 7.2, 4.4 +/- 4.7, 4.0 +/- 4.9) and PsA (14.7 +/- 6.4, 5.0 +/- 4.6, 5.3 +/- 6.4). Compared to patients with PA, the rate of serious adverse events [relative risk (RR) 1.39 (0.95-2.03, p = 0.08)] and nonserious [1.18 (1.02-1.35; p = 0.03)] adverse events were elevated. The rate of uveitis flares was significantly higher in PsA (3.3/100 patient-years), ExtOA (2.8/100 patient-years) and ERA (2.7/100 patient-years) than in rheumatoid factor (RF)-negative polyarticular JIA (1.3/100 pat.yrs) or RF-positive polyarticular JIA (0.27/100 patient-years). Reports on chronic inflammatory bowel disease were numerically more frequent in ExtOA, ERA and PsA. Administration of etanercept in patients with the JIA categories ExtOA, ERA and PsA is safe and very efficacious in children. Attention should be paid to the occurrence of extraarticular autoimmunopathies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Windschall, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Muller, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Horneff, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-417827
DOI:	10.1007/s10067-014-2744-6
Journal or Publication Title:	Clin. Rheumatol.
Volume:	34
Number:	1
Page Range:	S. 61 - 70
Date:	2015
Publisher:	SPRINGER LONDON LTD
Place of Publication:	LONDON
ISSN:	1434-9949
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language JUVENILE IDIOPATHIC ARTHRITIS; NECROSIS-FACTOR; ANKYLOSING-SPONDYLITIS; RANDOMIZED-TRIAL; DISEASE; UVEITIS; ALPHA; SOCIETY; DRUGS Multiple languages Rheumatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41782