Universität zu Köln

Lampe, Bjoern, Kroll, Nadine, Piso, Pompiliu, Forner, Dirk Michael and Mallmann, Peter (2015). Prognostic Significance of Sugarbaker's Peritoneal Cancer Index for the Operability of Ovarian Carcinoma. Int. J. Gynecol. Cancer, 25 (1). S. 135 - 145. LONDON: BMJ PUBLISHING GROUP. ISSN 1525-1438

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Abstract

Introduction: This study aimed to investigate Sugarbaker's peritoneal cancer index (PCI) as a prognostic indicator for the resectability of ovarian carcinoma (OC), as depicted in the study using the completeness of cytoreduction score (CCS). Currently, the intraoperative assessment of operability in OC surgery is primarily a subjective measurement that is dependent on the surgeon. Methods: The retrospective data from 98 patients with OC International Federation of Gynecology and Obstetrics (FIGO) III to IV who had received surgery between January 2010 and December 2011 were analyzed. The PCI and the CCS were determined retrospectively using surgical reports, histological findings, and intraoperative photographic documentation. Receiver operating characteristic curves and ordinal regression were applied to evaluate the predictability of CCS using the PCI. Results: Of 98 patients, 80 (81.6%) were staged FIGO III and 18 (18.4%) FIGO IV. A statistically significant correlation was demonstrated between the PCI and CCS (P < 0.01). A receiver operating characteristic curve with an area under the curve of 0.839 demonstrated the high precision in discrimination with which the PCI could predict the CCS. Using ordinal regression, it was possible to estimate the probabilities of achieving CCS 0, CCS 1, CCS 2, or CCS 3 for a given PCI (pseudo R-2 according to Cox and Snell 0.428, Nagelkerke 0.476, and McFadden 0.244). Conclusions: The PCI more precisely defined the heterogeneous group of patients with OC FIGO III. The PCI provided objectivity and reproducibility, and it seems to be a possible prognostic indicator for OC resectability.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lampe, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroll, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Piso, Pompiliu UNSPECIFIED UNSPECIFIED UNSPECIFIED Forner, Dirk Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-418093
DOI:	10.1097/IGC.0000000000000327
Journal or Publication Title:	Int. J. Gynecol. Cancer
Volume:	25
Number:	1
Page Range:	S. 135 - 145
Date:	2015
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1525-1438
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CYTOREDUCTIVE SURGERY; INTRAPERITONEAL CHEMOHYPERTHERMIA; SURVIVAL; SCORE; METHODOLOGIES; RESECTABILITY; CHEMOTHERAPY; VALIDATION; MANAGEMENT; IMPACT Multiple languages Oncology; Obstetrics & Gynecology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41809