Universität zu Köln

Gocht, Tilman ORCID: 0000-0002-2491-2050, Berggren, Elisabet, Ahr, Hans Juergen, Cotgreave, Ian, Cronin, Mark T. D., Daston, George, Hardy, Barry, Heinzle, Elmar, Hescheler, Juergen, Knight, Derek J., Mahony, Catherine, Peschanski, Marc, Schwarz, Michael, Thomas, Russell S., Verfaillie, Catherine ORCID: 0000-0001-7564-4079, White, Andrew and Whelan, Maurice (2015). The SEURAT-1 Approach towards Animal Free Human Safety Assessment. ALTEX-Altern. Anim. Exp., 32 (1). S. 9 - 25. HEILDEBERG: SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH. ISSN 1868-8551

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Abstract

SEURAT-1 is a European public-private research consortium that is working towards animal-free testing of chemical compounds and the highest level of consumer protection. A research strategy was formulated based on the guiding principle to adopt a toxicological mode-of-action framework to describe how any substance may adversely affect human health. The proof of the initiative will be in demonstrating the applicability of the concepts on which SEURAT-1 is built on three levels: (i) Theoretical prototypes for adverse outcome pathways are formulated based on knowledge already available in the scientific literature on investigating the toxicological modes-of-action leading to adverse outcomes (addressing mainly liver toxicity); (ii) adverse outcome pathway descriptions are used as a guide for the formulation of case studies to further elucidate the theoretical model and to develop integrated testing strategies for the prediction of certain toxicological effects (i.e., those related to the adverse outcome pathway descriptions); (iii) further case studies target the application of knowledge gained within SEURAT-1 in the context of safety assessment. The ultimate goal would be to perform ab initio predictions based on a complete understanding of toxicological mechanisms. In the near-term, it is more realistic that data from innovative testing methods will support read-across arguments. Both scenarios are addressed with case studies for improved safety assessment. A conceptual framework for a rational integrated assessment strategy emerged from designing the case studies and is discussed in the context of international developments focusing on alternative approaches for evaluating chemicals using the new 21st century tools for toxicity testing.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gocht, Tilman UNSPECIFIED orcid.org/0000-0002-2491-2050 UNSPECIFIED Berggren, Elisabet UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahr, Hans Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Cotgreave, Ian UNSPECIFIED UNSPECIFIED UNSPECIFIED Cronin, Mark T. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Daston, George UNSPECIFIED UNSPECIFIED UNSPECIFIED Hardy, Barry UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinzle, Elmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Hescheler, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Knight, Derek J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mahony, Catherine UNSPECIFIED UNSPECIFIED UNSPECIFIED Peschanski, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwarz, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomas, Russell S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Verfaillie, Catherine UNSPECIFIED orcid.org/0000-0001-7564-4079 UNSPECIFIED White, Andrew UNSPECIFIED UNSPECIFIED UNSPECIFIED Whelan, Maurice UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-418319
Journal or Publication Title:	ALTEX-Altern. Anim. Exp.
Volume:	32
Number:	1
Page Range:	S. 9 - 25
Date:	2015
Publisher:	SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH
Place of Publication:	HEILDEBERG
ISSN:	1868-8551
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTEGRATED TESTING STRATEGIES; STRESS-RESPONSE PATHWAYS; ADVERSE OUTCOME PATHWAY; ALTERNATIVE METHODS; RISK-ASSESSMENT; READ-ACROSS; IN-VITRO; TOXICITY; TOXICOLOGY; FRAMEWORK Multiple languages Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41831