Universität zu Köln

Malhotra, Rakesh, Marcelli, Daniele ORCID: 0000-0002-7650-8578, von Gersdorff, Gero, Grassmann, Aileen, Schaller, Mathias, Bayh, Inga, Scatizzi, Laura, Etter, Michael, Guinsburg, Adrian ORCID: 0000-0001-8770-1894, Barth, Claudia, Marelli, Cristina, Carioni, Paola, van der Sande, Frank, Kooman, Jeroen P., Liu, Eric, Toffelmire, Ted, Wang, Yuedong, Thijssen, Stephan, Usvyat, Len A. and Kotanko, Peter ORCID: 0000-0003-4373-412X (2015). Relationship of Neutrophil-to-Lymphocyte Ratio and Serum Albumin Levels with C-Reactive Protein in Hemodialysis Patients: Results from 2 International Cohort Studies. Nephron, 130 (4). S. 263 - 271. BASEL: KARGER. ISSN 2235-3186

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Abstract

Background/Aim: The neutrophil-to-lymphocyte ratio (NLR), defined as the neutrophil count divided by lymphocyte count, is an inexpensive and readily available parameter, which may serve as a surrogate for inflammation markers, such as C-reactive protein (CRP). The aim of this study was to determine the utility of NLR in the prediction of elevated CRP levels in hemodialysis (HD) patients. Methods: We analyzed 43,272 HD patients from 2 distinct cohorts within the Monitoring Dialysis Outcomes research collaboration in whom contemporaneous measurements of neutrophil and lymphocyte counts, serum albumin and CRP levels were available. Logistic regression was used to determine the relationship of trichotomized NLR (<2.5, 2.5-5 and >5.0) and albumin levels (<3.1, 3.1-4.0 and >4.0 g/dl) with elevated CRP levels (>10.0, >20.0 and >30.0 mg/l). Congruence of the prediction models was examined by comparing the regression parameters and by cross-validating each regression equation within the other cohort. Results: We found that NLR >5.0 vs. <2.5 (cohort 1: OR 2.3; p < 0.0001 and cohort 2: OR 2.0; p < 0.0001) was associated with CRP levels >10.0 mg/l. Stepwise increase in odds ratio for CRP >10.0 mg/l was observed with the combination of high NLR and low albumin levels (NLR >5.0 and albumin <3.1) (cohort 1: OR 7.6; p < 0.0001 and cohort 2: OR 11.9; p < 0.0001). Cross-validation of the 2 regression models revealed a predictive accuracy of 0.68 and 0.69 in the respective cohorts. Conclusion: This study suggests that NLR could serve as a potential surrogate marker for CRP. Our results may add to diagnostic abilities in settings where CRP is not measured routinely in HD patients. NLR is easy to integrate into daily practice and may be used as a marker of systemic inflammation. (C) 2015 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Malhotra, Rakesh UNSPECIFIED UNSPECIFIED UNSPECIFIED Marcelli, Daniele UNSPECIFIED orcid.org/0000-0002-7650-8578 UNSPECIFIED von Gersdorff, Gero UNSPECIFIED UNSPECIFIED UNSPECIFIED Grassmann, Aileen UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaller, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Bayh, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Scatizzi, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Etter, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Guinsburg, Adrian UNSPECIFIED orcid.org/0000-0001-8770-1894 UNSPECIFIED Barth, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Marelli, Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Carioni, Paola UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Sande, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Kooman, Jeroen P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Eric UNSPECIFIED UNSPECIFIED UNSPECIFIED Toffelmire, Ted UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Yuedong UNSPECIFIED UNSPECIFIED UNSPECIFIED Thijssen, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Usvyat, Len A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kotanko, Peter UNSPECIFIED orcid.org/0000-0003-4373-412X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-419518
DOI:	10.1159/000437005
Journal or Publication Title:	Nephron
Volume:	130
Number:	4
Page Range:	S. 263 - 271
Date:	2015
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	2235-3186
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CORONARY-HEART-DISEASE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; DIALYSIS PATIENTS; INFLAMMATION; MORTALITY; ASSOCIATION; BIOMARKERS; HOSPITALIZATION; INTERLEUKIN-6 Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41951