Universität zu Köln

Weiss, Carolin, Tursunova, Irada, Neuschmelting, Volker ORCID: 0000-0001-7527-6990, Lockau, Hannah, Nettekoven, Charlotte ORCID: 0000-0002-8944-4681, Oros-Peusquens, Ana-Maria ORCID: 0000-0002-8536-8044, Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Rehme, Anne K., Faymonville, Andrea Maria, Shah, N. Jon ORCID: 0000-0002-8151-6169, Langen, Karl Josef, Goldbrunner, Roland and Grefkes, Christian ORCID: 0000-0002-1656-720X (2015). Improved nTMS- and DTI-derived CST tractography through anatomical ROI seeding on anterior pontine level compared to internal capsule. NeuroImage-Clin., 7. S. 424 - 438. OXFORD: ELSEVIER SCI LTD. ISSN 2213-1582

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Abstract

Imaging of the course of the corticospinal tract (CST) by diffusion tensor imaging (DTI) is useful for function-preserving tumour surgery. The integration of functional localizer data into tracking algorithms offers to establish a direct structure-function relationship in DTI data. However, alterations of MRI signals in and adjacent to brain tumours often lead to spurious tracking results. We here compared the impact of subcortical seed regions placed at different positions and the influences of the somatotopic location of the cortical seed and clinical co-factors on fibre tracking plausibility in brain tumour patients. The CST of 32 patients with intracranial tumours was investigated by means of deterministic DTI and neuronavigated transcranial magnetic stimulation (nTMS). The cortical seeds were defined by the nTMS hot spots of the primary motor area (M1) of the hand, the foot and the tongue representation. The CST originating from the contralesional M1 hand area was mapped as intra-individual reference. As subcortical region of interests (ROI), we used the posterior limb of the internal capsule (PLIC) and/or the anterior inferior pontine region (aiP). The plausibility of the fibre trajectories was assessed by a-priori defined anatomical criteria. The following potential co-factors were analysed: Karnofsky Performance Scale (KPS), resting motor threshold (RMT), T1-CE tumour volume, T2 oedema volume, presence of oedema within the PLIC, the fractional anisotropy threshold (FAT) to elicit a minimum amount of fibres and the minimal fibre length. The results showed a higher proportion of plausible fibre tracts for the aiP-ROI compared to the PLIC-ROI. Low FAT values and the presence of peritumoural oedema within the PLIC led to less plausible fibre tracking results. Most plausible results were obtained when the FAT ranged above a cut-off of 0.105. In addition, there was a strong effect of somatotopic location of the seed ROI; best plausibility was obtained for the contralateral hand CST (100%), followed by the ipsilesional hand CST (>95%), the ipsilesional foot (>85%) and tongue (>75%) CST. In summary, we found that the aiP-ROI yielded better tracking results compared to the IC-ROI when using deterministic CST tractography in brain tumour patients, especially when the M1 hand area was tracked. In case of FAT values lower than 0.10, the result of the respective CST tractography should be interpreted with caution with respect to spurious tracking results. Moreover, the presence of oedema within the internal capsule should be considered a negative predictor for plausible CST tracking. (C) 2015 The Authors. Published by Elsevier Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weiss, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Tursunova, Irada UNSPECIFIED UNSPECIFIED UNSPECIFIED Neuschmelting, Volker UNSPECIFIED orcid.org/0000-0001-7527-6990 UNSPECIFIED Lockau, Hannah UNSPECIFIED UNSPECIFIED UNSPECIFIED Nettekoven, Charlotte UNSPECIFIED orcid.org/0000-0002-8944-4681 UNSPECIFIED Oros-Peusquens, Ana-Maria UNSPECIFIED orcid.org/0000-0002-8536-8044 UNSPECIFIED Stoffels, Gabriele UNSPECIFIED orcid.org/0000-0001-7114-1941 UNSPECIFIED Rehme, Anne K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Faymonville, Andrea Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, N. Jon UNSPECIFIED orcid.org/0000-0002-8151-6169 UNSPECIFIED Langen, Karl Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldbrunner, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-419539
DOI:	10.1016/j.nicl.2015.01.006
Journal or Publication Title:	NeuroImage-Clin.
Volume:	7
Page Range:	S. 424 - 438
Date:	2015
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	2213-1582
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRANIAL MAGNETIC STIMULATION; SUBCORTICAL ELECTRICAL-STIMULATION; IMAGING-BASED TRACTOGRAPHY; PRIMARY MOTOR CORTEX; WHITE-MATTER TRACTS; DIFFUSION-TENSOR; CORTICOSPINAL TRACT; FIBER TRACKING; SOMATOTOPIC ORGANIZATION; BRAIN-TUMORS Multiple languages Neuroimaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41953