Universität zu Köln

Kajava, Andrey V., Klopffleisch, Karsten ORCID: 0000-0002-6977-1386, Chen, Shuhua and Hofmann, Kay ORCID: 0000-0002-2289-9083 (2014). Evolutionary link between metazoan RHIM motif and prion-forming domain of fungal heterokaryon incompatibility factor HET-s/HET-s. Sci Rep, 4. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

The Rip homotypic interaction motif (RHIM) is a short, non-globular sequence stretch that mediates a key interaction of mammalian necroptosis signaling. In order to understand its unusual oligomerization properties, we set out to trace the evolutionary origins of the RHIM motif by identifying distantly related protein motifs that might employ the same binding mode. The RHIM motif was found to be related to the prion-forming domain of the HET-s protein, which oligomerizes by forming structurally well-characterized fibrils and is involved in fungal heterokaryon incompatibility. This evolutionary relationship explains the recently reported propensity of mammalian RHIM motifs to form amyloid fibrils, but suggests that these fibrils have a different structural architecture than currently assumed. These findings, together with numerous observations of RHIM-like motifs in immunity proteins from a wide range of species, provide insight to the modern innate immunity pathways in animals, plants and fungi.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kajava, Andrey V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klopffleisch, Karsten UNSPECIFIED orcid.org/0000-0002-6977-1386 UNSPECIFIED Chen, Shuhua UNSPECIFIED UNSPECIFIED UNSPECIFIED Hofmann, Kay UNSPECIFIED orcid.org/0000-0002-2289-9083 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-420299
DOI:	10.1038/srep07436
Journal or Publication Title:	Sci Rep
Volume:	4
Date:	2014
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTERACTING PROTEIN RIP; MIXED LINEAGE KINASE; PROGRAMMED NECROSIS; DOWNSTREAM; FILAMENTS; GENOME; SIRT2 Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/42029