Universität zu Köln

Babu, Vipin ORCID: 0000-0002-0001-8783, Hofmann, Kay ORCID: 0000-0002-2289-9083 and Schumacher, Bjoern (2014). A C. elegans homolog of the Cockayne syndrome complementation group A gene. DNA Repair, 24. S. 57 - 63. AMSTERDAM: ELSEVIER. ISSN 1568-7856

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Abstract

Cockayne syndrome (CS) is a debilitating and complex disorder that results from inherited mutations in the CS complementation genes A and B, CSA and CSB. The links between the molecular functions of the CS genes and the complex pathophysiology of CS are as of yet poorly understood and are the subject of intense debate. While mouse models reflect the complexity of CS, studies on simpler genetic models might shed new light on the consequences of CS mutations. Here we describe a functional homolog of the human CSA gene in Caenorhabditis elegans. Similar to its human counterpart, mutations in the nematode csa-1 gene lead to developmental growth defects as a consequence of DNA lesions. (C) 2014 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Babu, Vipin UNSPECIFIED orcid.org/0000-0002-0001-8783 UNSPECIFIED Hofmann, Kay UNSPECIFIED orcid.org/0000-0002-2289-9083 UNSPECIFIED Schumacher, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-421259
DOI:	10.1016/j.dnarep.2014.09.011
Journal or Publication Title:	DNA Repair
Volume:	24
Page Range:	S. 57 - 63
Date:	2014
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1568-7856
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NUCLEOTIDE EXCISION-REPAIR; COUPLED REPAIR; PROTEINS; NEMATODE Multiple languages Genetics & Heredity; Toxicology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/42125