Universität zu Köln

Mairinger, Fabian Dominik, Ting, Saskia ORCID: 0000-0003-1415-7714, Werner, Robert, Walter, Robert Fred Henry, Hager, Thomas, Vollbrecht, Claudia ORCID: 0000-0002-0861-001X, Christoph, Daniel, Worm, Karl, Mairinger, Thomas, Sheu-Grabellus, Sien-Yi, Theegarten, Dirk, Schmidt, Kurt Werner and Wohlschlaeger, Jeremias (2014). Different micro-RNA expression profiles distinguish subtypes of neuroendocrine tumors of the lung: results of a profiling study. Mod. Pathol., 27 (12). S. 1632 - 1641. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1530-0285

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Abstract

MicroRNAs (miRNAs) are a class of small (similar to 22 nucleotides), non-coding, highly conserved single-stranded RNAs with posttranscriptional regulatory features, including the regulation of cell proliferation, differentiation, survival, and apoptosis. They are deregulated in a broad variety of tumors showing characteristic expression patterns and can, thus, be used as a diagnostic tool. In contrast to non-small cell carcinoma of the lung neuroendocrine lung tumors, encompassing typical and atypical carcinoids, small cell lung cancer and large cell neuroendocrine lung cancer, no data about deregulation of tumor entity-specific miRNAs are available to date. miRNA expression differences might give useful information about the biological characteristics of these tumors, as well as serve as helpful markers.In 12 pulmonary neuroendocrine tumors classified as either typical carcinoid, atypical, large cell neuroendocrine or small cell lung cancer, screening for 763 miRNAs known to be involved in pulmonary cancerogenesis was conducted by performing 384-well TaqMan low-density array real-time qPCR. In the entire cohort, 44 miRNAs were identified, which showed a significantly different miRNA expression. For 12 miRNAs, the difference was highly significant (P < 0.01). Eight miRNAs showed a negative (miR-22, miR-29a, miR-29b, miR-29c, miR-367*; miR-504, miR-513C, miR-1200) and four miRNAs a positive (miR-18a, miR-15b*, miR-335*, miR-1201) correlation to the grade of tumor biology. The miRNAs let-7d; miR-19; miR-576-5p; miR-340*; miR-1286 are significantly associated with survival. Members of the miR-29 family seem to be extremely important in this group of tumors. We found a number of miRNAs, which showed a highly significant deregulation in pulmonary neuroendocrine tumors. Moreover, some of these deregulated miRNAs seem to allow discrimination of the various subtypes of pulmonary neuroendocrine tumors. Thus, the analysis of specific sets of miRNAs can be proposed as diagnostic and/or predictive markers in this group of neoplasias.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mairinger, Fabian Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED Ting, Saskia UNSPECIFIED orcid.org/0000-0003-1415-7714 UNSPECIFIED Werner, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Walter, Robert Fred Henry UNSPECIFIED UNSPECIFIED UNSPECIFIED Hager, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Vollbrecht, Claudia UNSPECIFIED orcid.org/0000-0002-0861-001X UNSPECIFIED Christoph, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Worm, Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED Mairinger, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Sheu-Grabellus, Sien-Yi UNSPECIFIED UNSPECIFIED UNSPECIFIED Theegarten, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Kurt Werner UNSPECIFIED UNSPECIFIED UNSPECIFIED Wohlschlaeger, Jeremias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-421813
DOI:	10.1038/modpathol.2014.74
Journal or Publication Title:	Mod. Pathol.
Volume:	27
Number:	12
Page Range:	S. 1632 - 1641
Date:	2014
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	NEW YORK
ISSN:	1530-0285
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACTIVATED PROTEIN-KINASE; THYROID-CARCINOMA; PROGNOSTIC VALUE; CANCER; MIRNA; GENE; OVEREXPRESSION; SUPPRESSOR; TISSUE; ROLES Multiple languages Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42181