Koziel, Rafal, Ruckenstuhl, Christoph ORCID: 0000-0002-4338-4679, Albertini, Eva, Neuhaus, Michael, Netzberger, Christine, Bust, Maria, Madeo, Frank, Wiesner, Rudolf J. and Jansen-Duerr, Pidder (2014). Methionine restriction slows down senescence in human diploid fibroblasts. Aging Cell, 13 (6). S. 1038 - 1049. HOBOKEN: WILEY. ISSN 1474-9726

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Abstract

Methionine restriction (MetR) extends lifespan in animal models including rodents. Using human diploid fibroblasts (HDF), we report here that MetR significantly extends their replicative lifespan, thereby postponing cellular senescence. MetR significantly decreased activity of mitochondrial complex IV and diminished the accumulation of reactive oxygen species. Lifespan extension was accompanied by a significant decrease in the levels of subunits of mitochondrial complex IV, but also complex I, which was due to a decreased translation rate of several mtDNA-encoded subunits. Together, these findings indicate that MetR slows down aging in human cells by modulating mitochondrial protein synthesis and respiratory chain assembly.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Koziel, RafalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruckenstuhl, ChristophUNSPECIFIEDorcid.org/0000-0002-4338-4679UNSPECIFIED
Albertini, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neuhaus, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Netzberger, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bust, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Madeo, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiesner, Rudolf J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jansen-Duerr, PidderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-421939
DOI: 10.1111/acel.12266
Journal or Publication Title: Aging Cell
Volume: 13
Number: 6
Page Range: S. 1038 - 1049
Date: 2014
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1474-9726
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MITOCHONDRIAL OXIDATIVE STRESS; CALORIC RESTRICTION; LIFE-SPAN; DIETARY RESTRICTION; CELLS; PROTEIN; DAMAGE; PHOSPHORYLATION; RESPIRATION; SUPPRESSIONMultiple languages
Cell Biology; Geriatrics & GerontologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/42193

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