Universität zu Köln

Humbert, P., Faivre, B., Veran, Y., Debure, C., Truchetet, F., Becherel, P. -A., Plantin, P., Kerihuel, J. -C., Eming, S. A., Dissemond, J., Weyandt, G., Kaspar, D., Smola, H. and Zoellner, P. (2014). Protease-modulating polyacrylate-based hydrogel stimulates wound bed preparation in venous leg ulcers - a randomized controlled trial. J. Eur. Acad. Dermatol. Venereol., 28 (12). S. 1742 - 1751. HOBOKEN: WILEY. ISSN 1468-3083

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Abstract

BackgroundStringent control of proteolytic activity represents a major therapeutic approach for wound-bed preparation. ObjectivesWe tested whether a protease-modulating polyacrylate- (PA-) containing hydrogel resulted in a more efficient wound-bed preparation of venous leg ulcers when compared to an amorphous hydrogel without known protease-modulating properties. MethodsPatients were randomized to the polyacrylate-based hydrogel (n=34) or to an amorphous hydrogel (n=41). Wound beds were evaluated by three blinded experts using photographs taken on days 0, 7 and 14. ResultsAfter 14 days of treatment there was an absolute decrease in fibrin and necrotic tissue of 37.629.9 percentage points in the PA-based hydrogel group and by 16.8 +/- 23.0 percentage points in the amorphous hydrogel group. The absolute increase in the proportion of ulcer area covered by granulation tissue was 36.0 +/- 27.4 percentage points in the PA-based hydrogel group and 14.5 +/- 22.0 percentage points in the control group. The differences between the groups were significant (decrease in fibrin and necrotic tissue P=0.004 and increase in granulation tissue P=0.0005, respectively). ConclusionIn particular, long-standing wounds profited from the treatment with the PA-based hydrogel. These data suggest that PA-based hydrogel dressings can stimulate normalization of the wound environment, particularly in hard-to-heal ulcers.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Humbert, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Faivre, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Veran, Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Debure, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Truchetet, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Becherel, P. -A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Plantin, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kerihuel, J. -C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eming, S. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dissemond, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weyandt, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaspar, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Smola, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoellner, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-421998
DOI:	10.1111/jdv.12400
Journal or Publication Title:	J. Eur. Acad. Dermatol. Venereol.
Volume:	28
Number:	12
Page Range:	S. 1742 - 1751
Date:	2014
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1468-3083
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOCAL-MANAGEMENT; MATRIX Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42199