Universität zu Köln

Thevis, Mario, Thomas, Andreas ORCID: 0000-0003-1199-0743 and Schaenzer, Wilhelm (2014). Detecting peptidic drugs, drug candidates and analogs in sports doping: current status and future directions. Expert Rev. Proteomics, 11 (6). S. 663 - 674. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1744-8387

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Abstract

With the growing availability of mature systems and strategies in biotechnology and the continuously expanding knowledge of cellular processes and involved biomolecules, human sports drug testing has become a considerably complex field in the arena of analytical chemistry. Proving the exogenous origin of peptidic drugs and respective analogs at lowest concentration levels in biological specimens (commonly blood, serum and urine) of rather limited volume is required to pursue an action against cheating athletes. Therefore, approaches employing chromatographic-mass spectrometric, electrophoretic, immunological and combined test methods have been required and developed. These allow detecting the misuse of peptidic compounds of lower (such as growth hormone-releasing peptides, ARA-290, TB-500, AOD-9604, CJC-1295, desmopressin, luteinizing hormone-releasing hormones, synacthen, etc.), intermediate (e.g., insulins, IGF-1 and analogs, full-length' mechano growth factor, growth hormone, chorionic gonadotropin, erythropoietin, etc.) and higher (e.g., stamulumab) molecular mass with desired specificity and sensitivity. A gap between the technically possible detection and the day-to-day analytical practice, however, still needs to be closed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomas, Andreas UNSPECIFIED orcid.org/0000-0003-1199-0743 UNSPECIFIED Schaenzer, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-422138
DOI:	10.1586/14789450.2014.965159
Journal or Publication Title:	Expert Rev. Proteomics
Volume:	11
Number:	6
Page Range:	S. 663 - 674
Date:	2014
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1744-8387
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN CHORIONIC-GONADOTROPIN; GROWTH-HORMONE ABUSE; ERYTHROPOIESIS-STIMULATING AGENTS; MASS-SPECTROMETRIC IDENTIFICATION; DRIED BLOOD SPOTS; HUMAN URINE; LIQUID-CHROMATOGRAPHY; FACTOR-I; OXYGEN CARRIERS; RECOMBINANT ERYTHROPOIETINS Multiple languages Biochemical Research Methods Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42213