Universität zu Köln

Puetz, Vanessa B., Kohn, Nils ORCID: 0000-0002-1954-2753, Dahmen, Brigitte, Zvyagintsev, Mikhail ORCID: 0000-0001-9521-042X, Schueppen, Andre, Schultz, Robert T., Heim, Christine M., Fink, Gereon R. ORCID: 0000-0002-8230-1856, Herpertz-Dahlmann, Beate and Konrad, Kerstin ORCID: 0000-0001-9039-2615 (2014). Neural Response to Social Rejection in Children With Early Separation Experiences. J. Am. Acad. Child Adolesc. Psychiatr., 53 (12). S. 1328 - 1338. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1527-5418

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Abstract

Objective: Nonhuman and human studies have documented the adverse effects of early life stress (ELS) on emotion regulation and underlying neural circuitry. Less is known about how these experiences shape social processes and neural circuitry. In this study, we thus investigated how ELS affects children's perception of, and neural response to, negative social experiences in a social exclusion paradigm (Cyberball). Method: Twenty-five foster or adopted children with ELS (age 10.6 +/- 1.8 years, 13 male and 12 female) and 26 matched nonseparated controls (age 10.38 +/- 1.7 years, 12 male and 14 female) took part in a Cyberball paradigm during functional magnetic resonance imaging (fMRI). Results: During peer rejection, children with ELS reported significantly more feelings of exclusion and frustration than nonseparated controls. On the neural level, children with ELS showed reduced activation in the dorsal anterior cingulate cortex (dACC) and dorsolateral prefrontal cortex (dlPFC), and reduced connectivity between dlPFC-dACC, areas previously implicated in affect regulation. Conversely, children with ELS showed increased neural activation in brain regions involved in memory, arousal, and threat-related processing (middle temporal gyrus, thalamus, ventral tegmental area) relative to controls during social exclusion. The number of separation experiences before entering the permanent family predicted reductions in fronto-cingulate recruitment. The relationship between early separations and self-reported exclusion was mediated by dlPFC activity. Conclusion: The findings suggest that ELS leads to alterations in neural circuitry implicated in the regulation of socioemotional processes. This neural signature may underlie foster children's differential reactivity to rejection in everyday life and could increase risk for developing affective disorders.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Puetz, Vanessa B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kohn, Nils UNSPECIFIED orcid.org/0000-0002-1954-2753 UNSPECIFIED Dahmen, Brigitte UNSPECIFIED UNSPECIFIED UNSPECIFIED Zvyagintsev, Mikhail UNSPECIFIED orcid.org/0000-0001-9521-042X UNSPECIFIED Schueppen, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Schultz, Robert T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heim, Christine M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Herpertz-Dahlmann, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED Konrad, Kerstin UNSPECIFIED orcid.org/0000-0001-9039-2615 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-422667
DOI:	10.1016/j.jaac.2014.09.004
Journal or Publication Title:	J. Am. Acad. Child Adolesc. Psychiatr.
Volume:	53
Number:	12
Page Range:	S. 1328 - 1338
Date:	2014
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1527-5418
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EARLY ADVERSE EXPERIENCES; EARLY-LIFE STRESS; CHILDHOOD MALTREATMENT; PREFRONTAL CORTEX; COGNITIVE CONTROL; EXCLUSION; ANXIETY; RISK; FMRI; ADOLESCENCE Multiple languages Psychology, Developmental; Pediatrics; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42266