Universität zu Köln

Feeser, Melanie, Fan, Yan ORCID: 0000-0002-4864-859X, Weigand, Anne, Hahn, Adam ORCID: 0000-0002-2232-4976, Gaertner, Matti, Aust, Sabine ORCID: 0000-0002-2638-161X, Boeker, Heinz, Bajbouj, Malek ORCID: 0000-0002-0073-3322 and Grimm, Simone (2014). The beneficial effect of oxytocin on avoidance-related facial emotion recognition depends on early life stress experience. Psychopharmacology, 231 (24). S. 4735 - 4745. NEW YORK: SPRINGER. ISSN 1432-2072

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Abstract

Previous studies have shown that oxytocin (OXT) enhances social cognitive processes. It has also been demonstrated that OXT does not uniformly facilitate social cognition. The effects of OXT administration strongly depend on the exposure to stressful experiences in early life. Emotional facial recognition is crucial for social cognition. However, no study has yet examined how the effects of OXT on the ability to identify emotional faces are altered by early life stress (ELS) experiences. Given the role of OXT in modulating social motivational processes, we specifically aimed to investigate its effects on the recognition of approach- and avoidance-related facial emotions. In a double-blind, between-subjects, placebo-controlled design, 82 male participants performed an emotion recognition task with faces taken from the Karolinska Directed Emotional Faces set. We clustered the six basic emotions along the dimensions approach (happy, surprise, anger) and avoidance (fear, sadness, disgust). ELS was assessed with the Childhood Trauma Questionnaire (CTQ). Our results showed that OXT improved the ability to recognize avoidance-related emotional faces as compared to approach-related emotional faces. Whereas the performance for avoidance-related emotions in participants with higher ELS scores was comparable in both OXT and placebo condition, OXT enhanced emotion recognition in participants with lower ELS scores. Independent of OXT administration, we observed increased emotion recognition for avoidance-related faces in participants with high ELS scores. Our findings suggest that the investigation of OXT on social recognition requires a broad approach that takes ELS experiences as well as motivational processes into account.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Feeser, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Fan, Yan UNSPECIFIED orcid.org/0000-0002-4864-859X UNSPECIFIED Weigand, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Hahn, Adam UNSPECIFIED orcid.org/0000-0002-2232-4976 UNSPECIFIED Gaertner, Matti UNSPECIFIED UNSPECIFIED UNSPECIFIED Aust, Sabine UNSPECIFIED orcid.org/0000-0002-2638-161X UNSPECIFIED Boeker, Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Bajbouj, Malek UNSPECIFIED orcid.org/0000-0002-0073-3322 UNSPECIFIED Grimm, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-422835
DOI:	10.1007/s00213-014-3631-1
Journal or Publication Title:	Psychopharmacology
Volume:	231
Number:	24
Page Range:	S. 4735 - 4745
Date:	2014
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-2072
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VENTRAL TEGMENTAL AREA; INTRANASAL OXYTOCIN; SOCIAL-BEHAVIOR; HUMAN BRAIN; MATERNAL-BEHAVIOR; AMYGDALA RESPONSE; NEURAL CIRCUITRY; INCREASES TRUST; HUMANS; FACES Multiple languages Neurosciences; Pharmacology & Pharmacy; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42283