Universität zu Köln

Deprest, Jan ORCID: 0000-0002-4920-945X, Brady, Paul, Nicolaides, Kypros, Benachi, Alexandra, Berg, Christoph, Vermeesch, Joris, Gardener, Glenn ORCID: 0000-0002-8123-0718 and Gratacos, Eduard ORCID: 0000-0002-7405-7224 (2014). Prenatal management of the fetus with isolated congenital diaphragmatic hernia in the era of the TOTAL trial. Semin. Fetal Neonatal Med., 19 (6). S. 338 - 349. OXFORD: ELSEVIER SCI LTD. ISSN 1878-0946

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Abstract

Congenital diaphragmatic hernia (CDH) may be isolated or associated with other structural anomalies, the latter with poor prognosis. The defect allows viscera to herniate through the defect into the chest, competing for space with the developing lungs. At birth, pulmonary hypoplasia leads to respiratory insufficiency and persistent pulmonary hypertension that is lethal in up to 30% of patients. When isolated, survival chances can be predicted by antenatal measurement of lung size and liver herniation. Chromosomal microarrays and exome sequencing contribute to understanding genetic factors underlying isolated CDH. Prenatal intervention aims at stimulating lung development, clinically achieved by percutaneous fetal endoscopic tracheal occlusion (FETO) under local anesthesia. The Tracheal Occlusion To Accelerate Lung growth trial (www.totaltrial.eu) is an international randomized trial investigating the role of fetal therapy for severe and moderate pulmonary hypoplasia. Despite an apparent increase in survival following FETO, the search for lesser invasive and more potent prenatal interventions must continue. (C) 2014 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Deprest, Jan UNSPECIFIED orcid.org/0000-0002-4920-945X UNSPECIFIED Brady, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Nicolaides, Kypros UNSPECIFIED UNSPECIFIED UNSPECIFIED Benachi, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Vermeesch, Joris UNSPECIFIED UNSPECIFIED UNSPECIFIED Gardener, Glenn UNSPECIFIED orcid.org/0000-0002-8123-0718 UNSPECIFIED Gratacos, Eduard UNSPECIFIED orcid.org/0000-0002-7405-7224 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-422872
DOI:	10.1016/j.siny.2014.09.006
Journal or Publication Title:	Semin. Fetal Neonatal Med.
Volume:	19
Number:	6
Page Range:	S. 338 - 349
Date:	2014
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1878-0946
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDOSCOPIC TRACHEAL OCCLUSION; FETAL LUNG-VOLUME; HEAD CIRCUMFERENCE RATIO; MESENCHYMAL STEM-CELLS; LIVER HERNIATION; AMNIOTIC-FLUID; PULMONARY-HYPERTENSION; POSTNATAL MANAGEMENT; HYPOPLASTIC LUNG; BODY VOLUME Multiple languages Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42287