Universität zu Köln

Golla, Heidrun, Ahmad, Maryam Ale, Galushko, Maren, Hampl, Juergen, Maarouf, Mohammad, Schroeter, Michael, Herrlinger, Ulrich, Hellmich, Martin and Voltz, Raymond (2014). Glioblastoma multiforme from diagnosis to death: a prospective, hospital-based, cohort, pilot feasibility study of patient reported symptoms and needs. Support. Care Cancer, 22 (12). S. 3341 - 3353. NEW YORK: SPRINGER. ISSN 1433-7339

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Abstract

Glioblastoma (GBM) patients have many palliative care (PC) issues. To date, there are no studies examining the prospective usage of validated PC assessment tools as patient reported outcome measures for GBM patients. GBM patients' PC issues were assessed from diagnosis to death or for at least 12 months every 7 weeks (+/- 8 days) using semi-structured interviews and the Hospice and Palliative Care Evaluation (HOPE, including Eastern Cooperative Oncology Group (ECOG) performance status, 17 items) and the Palliative Outcome Scale (POS, 11 items). Data from patients who died within 12 months of the last patient's enrollment were evaluated using summarizing content analysis, visual graphical analysis (VGA), and linear mixed models for repeated measures. Nineteen of 33 patients screened were enrolled; two dropped out and four were still alive at the end of the study. The remaining 13 were assessed at 59 points until death (time range 4-68 weeks; 1-10 contacts per patient; assessment: self, 33; joint, 8; external, 18). VGA of the HOPE and POS data, including all 1,652 assessed item data, showed consistent trajectory profiles for 14 of 28 items: 10 were increasing (meaning symptom worsening) and comprised predominantly psychosocial issues and care dependency. Type of assessment partly interacted with time, however, not qualitatively so. Analysis of semi-structured interviews revealed delayed interactions with PC/hospice services and numerous neuropsychiatric problems not detected by HOPE and POS. Prospective self-assessment of GBM patients' PC issues is feasible. However, disease progression may necessitate further, external assessment. Modification of existing PC assessment tools is needed to detect GBM-specific issues.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Golla, Heidrun UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahmad, Maryam Ale UNSPECIFIED UNSPECIFIED UNSPECIFIED Galushko, Maren UNSPECIFIED UNSPECIFIED UNSPECIFIED Hampl, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Maarouf, Mohammad UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeter, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Herrlinger, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Voltz, Raymond UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-422891
DOI:	10.1007/s00520-014-2384-z
Journal or Publication Title:	Support. Care Cancer
Volume:	22
Number:	12
Page Range:	S. 3341 - 3353
Date:	2014
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-7339
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; HIGH-GRADE GLIOMA; PRIMARY BRAIN-TUMORS; CARE OUTCOME SCALE; PALLIATIVE CARE; VALIDATION; CAREGIVERS; CANCER; PHASE; SUPPORT Multiple languages Oncology; Health Care Sciences & Services; Rehabilitation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42289