Universität zu Köln

Calderwood, Alexander, Morris, Richard J. and Kopriva, Stanislav ORCID: 0000-0002-7416-6551 (2014). Predictive sulfur metabolism - a field in flux. Front. Plant Sci., 5. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-462X

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Abstract

The key role of sulfur metabolites in response to biotic and abiotic stress in plants, as well as their importance in diet and health has led to a significant interest and effort in trying to understand and manipulate the production of relevant compounds. Metabolic engineering utilizes a set of theoretical tools to help rationally design modifications that enhance the production of a desired metabolite. Such approaches have proven their value in bacterial systems, however, the paucity of success stories to date in plants, suggests that challenges remain. Here, we review the most commonly used methods for understanding metabolic flux, focusing on the sulfur assimilatory pathway. We highlight known issues with both experimental and theoretical approaches, as well as presenting recent methods for integrating different modeling strategies, and progress toward an understanding of flux at the whole plant level.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Calderwood, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Morris, Richard J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kopriva, Stanislav UNSPECIFIED orcid.org/0000-0002-7416-6551 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-423173
DOI:	10.3389/fpls.2014.00646
Journal or Publication Title:	Front. Plant Sci.
Volume:	5
Date:	2014
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-462X
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Botanical Institute
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ADENOSINE 5'-PHOSPHOSULFATE REDUCTASE; ASSIMILATORY SULFATE REDUCTION; ARABIDOPSIS-THALIANA; BALANCE ANALYSIS; ESCHERICHIA-COLI; ENZYME-ACTIVITIES; SYSTEMS-BIOLOGY; 5-PHOSPHOSULFATE REDUCTASE; NATURAL VARIATION; STRESS CONDITIONS Multiple languages Plant Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/42317