Universität zu Köln

Nkuipou-Kenfack, Esther, Koeck, Thomas, Mischak, Harald ORCID: 0000-0003-0323-0306, Pich, Andreas, Schanstra, Joost P., Zuerbig, Petra and Schumacher, Bjoern (2014). Proteome analysis in the assessment of ageing. Ageing Res. Rev., 18. S. 74 - 86. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-9649

Full text not available from this repository.

Abstract

Based on demographic trends, the societies in many developed countries are facing an increasing number and proportion of people over the age of 65. The raise in elderly populations along with improved health-care will be concomitant with an increased prevalence of ageing-associated chronic conditions like cardiovascular, renal, and respiratory diseases, arthritis, dementia, and diabetes mellitus. This is expected to pose unprecedented challenges both for individuals and societies and their health care systems. An ultimate goal of ageing research is therefore the understanding of physiological ageing and the achievement of 'healthy' ageing by decreasing age-related pathologies. However, on a molecular level, ageing is a complex multi-mechanistic process whose contributing factors may vary individually, partly overlap with pathological alterations, and are often poorly understood. Proteome analysis potentially allows modelling of these multifactorial processes. This review summarises recent proteomic research on age-related changes identified in animal models and human studies. We combined this information with pathway analysis to identify molecular mechanisms associated with ageing. We identified some molecular pathways that are affected in most or even all organs and others that are organ-specific. However, appropriately powered studies are needed to confirm these findings based in in silico evaluation. (C) 2014 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nkuipou-Kenfack, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED Koeck, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Mischak, Harald UNSPECIFIED orcid.org/0000-0003-0323-0306 UNSPECIFIED Pich, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schanstra, Joost P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zuerbig, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumacher, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-423863
DOI:	10.1016/j.arr.2014.09.002
Journal or Publication Title:	Ageing Res. Rev.
Volume:	18
Page Range:	S. 74 - 86
Date:	2014
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-9649
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UBIQUITIN-PROTEASOME SYSTEM; MASS-SPECTROMETRY; CAENORHABDITIS-ELEGANS; LIQUID-CHROMATOGRAPHY; EXTRACELLULAR-MATRIX; MOLECULAR-MECHANISMS; CELLULAR SENESCENCE; LEFT-VENTRICLE; LABILE IRON; KINASE-C Multiple languages Cell Biology; Geriatrics & Gerontology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42386