Universität zu Köln

Hos, D., van Essen, T. H., Bock, F., Chou, C-H., Pan, H-A., Lin, C-C., Huang, M-C, Chen, S-C, Cursiefen, C. and Jager, M. J. (2014). Decellularized collagen matrix from tilapia fish scales for corneal reconstruction (BioCornea). Ophthalmologe, 111 (11). S. 1027 - 1033. NEW YORK: SPRINGER. ISSN 1433-0423

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Abstract

The worldwide need for donor corneal tissue clearly exceeds the availability of transplantable human tissue; therefore, recent efforts aim to identify and characterize alternative tissues, such as decellularized collagen scaffolds. The transparent fish scales of tilapia (Oreochromis mossambicus) were analyzed as a potential alternative for corneal reconstruction (BioCornea). The article gives a review of the literature and own preliminary results. After decellularization the tissue characteristics of the fish scales, the repopulation with corneal epithelium and stromal cells, immunogenicity, the feasibility of corneal transplantation and the angiogenic properties were analyzed in vitro and in various animal models. The fish scales mainly consist of collagen type I and show an architecture that is similar to the human cornea. Corneal epithelium and stromal cells are able to grow over and into the scaffold. It is possible to transplant fish scales in various animal models without severe inflammatory responses. Furthermore, in mice, less blood and lymphatic vessels grow into the xenograft when compared to conventional allogenic transplants. Preliminary results with decellularized tilapia fish scales as an alternative for corneal reconstruction (BioCornea) are promising.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hos, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Essen, T. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bock, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chou, C-H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pan, H-A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lin, C-C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Huang, M-C UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, S-C UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jager, M. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-424149
DOI:	10.1007/s00347-013-3011-y
Journal or Publication Title:	Ophthalmologe
Volume:	111
Number:	11
Page Range:	S. 1027 - 1033
Date:	2014
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-0423
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIGH-RISK KERATOPLASTY; IMMUNE PRIVILEGE; NEOVASCULARIZATION; TRANSPLANTATION; ALLOGRAFTS; BLINDNESS Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42414