Universität zu Köln

Adamchic, Ilya, Hauptmann, Christian, Barnikol, Utako Brigit, Pawelczyk, Norbert, Popovych, Oleksandr, Barnikol, Thomas Theo, Silchenko, Alexander ORCID: 0000-0001-5591-238X, Volkmann, Jens ORCID: 0000-0002-9570-593X, Deuschl, Guenter, Meissner, Wassilios G., Maarouf, Mohammad, Sturm, Volker, Freund, Hans-Joachim and Tass, Peter Alexander (2014). Coordinated Reset Neuromodulation for Parkinson's Disease: Proof-of-Concept Study. Mov. Disord., 29 (13). S. 1679 - 1685. HOBOKEN: WILEY-BLACKWELL. ISSN 1531-8257

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Abstract

BackgroundThe discovery of abnormal synchronization of neuronal activity in the basal ganglia in Parkinson's disease (PD) has prompted the development of novel neuromodulation paradigms. Coordinated reset neuromodulation intends to specifically counteract excessive synchronization and to induce cumulative unlearning of pathological synaptic connectivity and neuronal synchrony. MethodsIn this prospective case series, six PD patients were evaluated before and after coordinated reset neuromodulation according to a standardized protocol that included both electrophysiological recordings and clinical assessments. ResultsCoordinated reset neuromodulation of the subthalamic nucleus (STN) applied to six PD patients in an externalized setting during three stimulation days induced a significant and cumulative reduction of beta band activity that correlated with a significant improvement of motor function. ConclusionsThese results highlight the potential effects of coordinated reset neuromodulation of the STN in PD patients and encourage further development of this approach as an alternative to conventional high-frequency deep brain stimulation in PD. (c) 2014 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Adamchic, Ilya UNSPECIFIED UNSPECIFIED UNSPECIFIED Hauptmann, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Barnikol, Utako Brigit UNSPECIFIED UNSPECIFIED UNSPECIFIED Pawelczyk, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Popovych, Oleksandr UNSPECIFIED UNSPECIFIED UNSPECIFIED Barnikol, Thomas Theo UNSPECIFIED UNSPECIFIED UNSPECIFIED Silchenko, Alexander UNSPECIFIED orcid.org/0000-0001-5591-238X UNSPECIFIED Volkmann, Jens UNSPECIFIED orcid.org/0000-0002-9570-593X UNSPECIFIED Deuschl, Guenter UNSPECIFIED UNSPECIFIED UNSPECIFIED Meissner, Wassilios G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maarouf, Mohammad UNSPECIFIED UNSPECIFIED UNSPECIFIED Sturm, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Freund, Hans-Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Tass, Peter Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-424540
DOI:	10.1002/mds.25923
Journal or Publication Title:	Mov. Disord.
Volume:	29
Number:	13
Page Range:	S. 1679 - 1685
Date:	2014
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1531-8257
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP-BRAIN-STIMULATION; HIGH-FREQUENCY STIMULATION Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42454