Universität zu Köln

Alexopoulos, Panagiotis, Kriett, Laura, Haller, Bernhard ORCID: 0000-0002-9723-393X, Klupp, Elisabeth, Gray, Katherine, Grimmer, Timo, Laskaris, Nikolaos, Foerster, Stefan, Perneczky, Robert ORCID: 0000-0003-1981-7435, Kurz, Alexander, Drzezga, Alexander, Fellgiebel, Andreas and Yakushev, Igor (2014). Limited agreement between biomarkers of neuronal injury at different stages of Alzheimer's disease. Alzheimers. Dement., 10 (6). S. 684 - 690. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1552-5279

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Abstract

New diagnostic criteria for Alzheimer's disease (AD) treat different biomarkers of neuronal injury as equivalent. Here, we quantified the degree of agreement between hippocampal volume on structural magnetic resonance imaging, regional glucose metabolism on positron emission tomography, and levels of phosphorylated tau in cerebrospinal fluid (CSF) in 585 subjects from all phases of the AD Neuroimaging Initiative. The overall chance-corrected agreement was poor (Cohen kappa, 0.24-0.34), in accord with a high rate of conflicting findings (26%-41%). Neither diagnosis nor APOE epsilon 4 status significantly influenced the distribution of agreement between the biomarkers. The degree of agreement tended to be higher in individuals with abnormal versus normal CSF beta-am-yloid (A beta(1-42)) levels. Prospective diagnostic criteria for AD should address the relative importance of markers of neuronal injury and elaborate a way of dealing with conflicting biomarker findings. (C) 2014 The Alzheimer's Association. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Alexopoulos, Panagiotis UNSPECIFIED UNSPECIFIED UNSPECIFIED Kriett, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Haller, Bernhard UNSPECIFIED orcid.org/0000-0002-9723-393X UNSPECIFIED Klupp, Elisabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Gray, Katherine UNSPECIFIED UNSPECIFIED UNSPECIFIED Grimmer, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Laskaris, Nikolaos UNSPECIFIED UNSPECIFIED UNSPECIFIED Foerster, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Perneczky, Robert UNSPECIFIED orcid.org/0000-0003-1981-7435 UNSPECIFIED Kurz, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Fellgiebel, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Yakushev, Igor UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-425015
DOI:	10.1016/j.jalz.2014.03.006
Journal or Publication Title:	Alzheimers. Dement.
Volume:	10
Number:	6
Page Range:	S. 684 - 690
Date:	2014
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1552-5279
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILD COGNITIVE IMPAIRMENT; NATIONAL INSTITUTE; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; RECOMMENDATIONS; DEMENTIA; ADNI; CORE Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42501