Universität zu Köln

Herz, Damian Marc, Florin, Esther ORCID: 0000-0001-8276-2508, Christensen, Mark Schram, Reck, Christiane, Barbe, Michael Thomas, Tscheuschler, Maike Karoline, Tittgemeyer, Marc, Siebner, Hartwig Roman and Timmermann, Lars (2014). Dopamine Replacement Modulates Oscillatory Coupling Between Premotor and Motor Cortical Areas in Parkinson's Disease. Cereb. Cortex, 24 (11). S. 2873 - 2884. CARY: OXFORD UNIV PRESS INC. ISSN 1460-2199

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Abstract

Efficient neural communication between premotor and motor cortical areas is critical for manual motor control. Here, we used high-density electroencephalography to study cortical connectivity in patients with Parkinson's disease (PD) and age-matched healthy controls while they performed repetitive movements of the right index finger at maximal repetition rate. Multiple source beamformer analysis and dynamic causal modeling were used to assess oscillatory coupling between the lateral premotor cortex (lPM), supplementary motor area (SMA), and primary motor cortex (M1) in the contralateral hemisphere. Elderly healthy controls showed task-related modulation in connections from lPM to SMA and M1, mainly within the gamma-band (> 30 Hz). Nonmedicated PD patients also showed task-related gamma-gamma coupling from lPM to M1, but gamma coupling from lPM to SMA was absent. Levodopa reinstated physiological gamma-gamma coupling from lPM to SMA and significantly strengthened coupling in the feedback connection from M1 to lPM expressed as beta-beta as well as theta-beta coupling. Enhancement in cross-frequency theta-beta coupling from M1 to lPM was correlated with levodopa-induced improvement in motor function. The results show that PD is associated with an altered neural communication between premotor and motor cortical areas, which can be modulated by dopamine replacement.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herz, Damian Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Florin, Esther UNSPECIFIED orcid.org/0000-0001-8276-2508 UNSPECIFIED Christensen, Mark Schram UNSPECIFIED UNSPECIFIED UNSPECIFIED Reck, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbe, Michael Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Tscheuschler, Maike Karoline UNSPECIFIED UNSPECIFIED UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Siebner, Hartwig Roman UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-425051
DOI:	10.1093/cercor/bht140
Journal or Publication Title:	Cereb. Cortex
Volume:	24
Number:	11
Page Range:	S. 2873 - 2884
Date:	2014
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1460-2199
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DUAL-TASK PERFORMANCE; BASAL GANGLIA; SUBTHALAMIC NUCLEUS; EFFECTIVE CONNECTIVITY; CORTICOMUSCULAR COHERENCE; SENSORIMOTOR INTEGRATION; FINGER MOVEMENTS; NEURAL BASIS; 2 PARTS; CORTEX Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42505