Universität zu Köln

Michel, Chantal ORCID: 0000-0003-1165-6681, Ruhrmann, Stephan ORCID: 0000-0002-6022-2364, Schimmelmann, Benno G., Klosterkoetter, Joachim and Schultze-Lutter, Frauke (2014). A Stratified Model for Psychosis Prediction in Clinical Practice. Schizophr. Bull., 40 (6). S. 1533 - 1543. OXFORD: OXFORD UNIV PRESS. ISSN 1745-1701

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Abstract

Objective: Impaired cognition is an important dimension in psychosis and its at-risk states. Research on the value of impaired cognition for psychosis prediction in at-risk samples, however, mainly relies on study-specific sample means of neurocognitive tests, which unlike widely available general test norms are difficult to translate into clinical practice. The aim of this study was to explore the combined predictive value of at-risk criteria and neurocognitive deficits according to test norms with a risk stratification approach. Method: Potential predictors of psychosis (neurocognitive deficits and at-risk criteria) over 24 months were investigated in 97 at-risk patients. Results: The final prediction model included (1) at-risk criteria (attenuated psychotic symptoms plus subjective cognitive disturbances) and (2) a processing speed deficit (digit symbol test). The model was stratified into 4 risk classes with hazard rates between 0.0 (both predictors absent) and 1.29 (both predictors present). Conclusions: The combination of a processing speed deficit and at-risk criteria provides an optimized stratified risk assessment. Based on neurocognitive test norms, the validity of our proposed 3 risk classes could easily be examined in independent at-risk samples and, pending positive validation results, our approach could easily be applied in clinical practice in the future.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Michel, Chantal UNSPECIFIED orcid.org/0000-0003-1165-6681 UNSPECIFIED Ruhrmann, Stephan UNSPECIFIED orcid.org/0000-0002-6022-2364 UNSPECIFIED Schimmelmann, Benno G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkoetter, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Schultze-Lutter, Frauke UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-425372
DOI:	10.1093/schbul/sbu025
Journal or Publication Title:	Schizophr. Bull.
Volume:	40
Number:	6
Page Range:	S. 1533 - 1543
Date:	2014
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1745-1701
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ULTRA-HIGH RISK; UNTREATED PSYCHOSIS; PROCESSING SPEED; NEUROCOGNITIVE PREDICTORS; COGNITIVE IMPAIRMENT; POSITIVE SYMPTOMS; BIRTH COHORT; YOUNG-ADULTS; AT-RISK; SCHIZOPHRENIA Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42537