Universität zu Köln

Heermann, Philipp, Hedderich, Dennis M., Paul, Matthias, Schuelke, Christoph, Kroeger, Jan Robert, Baessler, Bettina ORCID: 0000-0002-3244-3864, Wichter, Thomas, Maintz, David, Waltenberger, Johannes, Heindel, Walter and Bunck, Alexander C. (2014). Biventricular myocardial strain analysis in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) using cardiovascular magnetic resonance feature tracking. J. Cardiov. Magn. Reson., 16. LONDON: BMC. ISSN 1532-429X

Full text not available from this repository.

Abstract

Background: Fibrofatty degeneration of myocardium in ARVC is associated with wall motion abnormalities. The aim of this study was to examine whether Cardiovascular Magnetic Resonance (CMR) based strain analysis using feature tracking (FT) can serve as a quantifiable measure to confirm global and regional ventricular dysfunction in ARVC patients and support the early detection of ARVC. Methods: We enrolled 20 patients with ARVC, 30 with borderline ARVC and 22 subjects with a positive family history but no clinical signs of a manifest ARVC. 10 healthy volunteers (HV) served as controls. 15 ARVC patients received genotyping for Plakophilin-2 mutation (PKP-2), of which 7 were found to be positive. Cine MR datasets of all subjects were assessed for myocardial strain using FT (TomTec Diogenes Software). Global strain and strain rate in radial, circumferential and longitudinal mode were assessed for the right and left ventricle. In addition strain analysis at a segmental level was performed for the right ventricular free wall. Results: RV global longitudinal strain rates in ARVC (-0.68 +/- 0.36 sec(-1)) and borderline ARVC (-0.85 +/- 0.36 sec(-1)) were significantly reduced in comparison with HV (-1.38 +/- 0.52 sec(-1), p <= 0.05). Furthermore, in ARVC patients RV global circumferential strain and strain rates at the basal level were significantly reduced compared with HV (strain: -5.1 +/- 2.7 vs. -9.2 +/- 3.6%; strain rate: -0.31 +/- 0.13 sec(-1) vs. -0.61 +/- 0.21 sec(-1)). Even for patients with ARVC or borderline ARVC and normal RV ejection fraction (n= 30) global longitudinal strain rate proved to be significantly reduced compared with HV (-0.9 +/- 0.3 vs. -1.4 +/- 0.5 sec(-1); p < 0.005). In ARVC patients with PKP-2 mutation there was a clear trend towards a more pronounced impairment in RV global longitudinal strain rate. On ROC analysis RV global longitudinal strain rate and circumferential strain rate at the basal level proved to be the best discriminators between ARVC patients and HV (AUC: 0.9 and 0.92, respectively). Conclusion: CMR based strain analysis using FT is an objective and useful measure for quantification of wall motion abnormalities in ARVC. It allows differentiation between manifest or borderline ARVC and HV, even if ejection fraction is still normal.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heermann, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Hedderich, Dennis M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Paul, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuelke, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroeger, Jan Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Baessler, Bettina UNSPECIFIED orcid.org/0000-0002-3244-3864 UNSPECIFIED Wichter, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Waltenberger, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindel, Walter UNSPECIFIED UNSPECIFIED UNSPECIFIED Bunck, Alexander C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-425876
DOI:	10.1186/s12968-014-0075-z
Journal or Publication Title:	J. Cardiov. Magn. Reson.
Volume:	16
Date:	2014
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1532-429X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ECHOCARDIOGRAPHIC SPECKLE TRACKING; HEALTHY-SUBJECTS; WALL-MOTION; DYSPLASIA/CARDIOMYOPATHY; DIAGNOSIS; DEFORMATION; MECHANICS; REPRODUCIBILITY; ABNORMALITIES; PLAKOPHILIN-2 Multiple languages Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42587