Universität zu Köln

Andereggen, Lukas ORCID: 0000-0003-1764-688X, Neuschmelting, Volker ORCID: 0000-0001-7527-6990, von Gunten, Michael, Widmer, Hans Rudolf ORCID: 0000-0003-3378-8765, Takala, Jukka, Jakob, Stephan M., Fandino, Javier and Marbacher, Serge ORCID: 0000-0001-6305-7571 (2014). The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects. J. Vis. Exp. (92). CAMBRIDGE: JOURNAL OF VISUALIZED EXPERIMENTS. ISSN 1940-087X

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Abstract

Early brain injury and delayed cerebral vasospasm both contribute to unfavorable outcomes after subarachnoid hemorrhage (SAH). Reproducible and controllable animal models that simulate both conditions are presently uncommon. Therefore, new models are needed in order to mimic human pathophysiological conditions resulting from SAH. This report describes the technical nuances of a rabbit blood-shunt SAH model that enables control of intracerebral pressure (ICP). An extracorporeal shunt is placed between the arterial system and the subarachnoid space, which enables examiner-independent SAH in a closed cranium. Step-by-step procedural instructions and necessary equipment are described, as well as technical considerations to produce the model with minimal mortality and morbidity. Important details required for successful surgical creation of this robust, simple and consistent ICP-controlled SAH rabbit model are described.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Andereggen, Lukas UNSPECIFIED orcid.org/0000-0003-1764-688X UNSPECIFIED Neuschmelting, Volker UNSPECIFIED orcid.org/0000-0001-7527-6990 UNSPECIFIED von Gunten, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Widmer, Hans Rudolf UNSPECIFIED orcid.org/0000-0003-3378-8765 UNSPECIFIED Takala, Jukka UNSPECIFIED UNSPECIFIED UNSPECIFIED Jakob, Stephan M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fandino, Javier UNSPECIFIED UNSPECIFIED UNSPECIFIED Marbacher, Serge UNSPECIFIED orcid.org/0000-0001-6305-7571 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-426135
DOI:	10.3791/52132
Journal or Publication Title:	J. Vis. Exp.
Number:	92
Date:	2014
Publisher:	JOURNAL OF VISUALIZED EXPERIMENTS
Place of Publication:	CAMBRIDGE
ISSN:	1940-087X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DELAYED CEREBRAL VASOSPASM; EARLY BRAIN-INJURY; INTRACRANIAL-PRESSURE; IN-VIVO; RAT; FLOW Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42613