Universität zu Köln

Herberg, Ulrike, Berg, Christoph, Geipel, Annegret, Gembruch, Ulrich ORCID: 0000-0001-8284-4669 and Breuer, Johannes (2014). Foetal therapy: what works? Closed interatrial septum. Cardiol. Young, 24. S. 47 - 55. CAMBRIDGE: CAMBRIDGE UNIV PRESS. ISSN 1467-1107

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Abstract

Hypoplastic left-heart syndrome and critical aortic stenosis with severely restricted or intact foramen ovale are associated with high neonatal mortality and poor long-term outcome. Despite accurate foetal diagnosis and successful postnatal catheter-based and surgical intervention, the 1-month survival rate is about 33%. Changes in pulmonary vascular architecture resulting in pulmonary hypertension result in important long-term morbidity. Prenatal relief of left atrial and pulmonary hypertension may promote normal pulmonary vascular and parenchymal development and improve short- and long-term outcomes. Foetal atrial balloon septostomy, laser perforation, and stenting of the foetal interatrial septum are the current options for foetal therapy. This paper provides an overview of foetal diagnosis, selection of patients for foetal intervention, and interventional techniques, and also reviews the current status of foetal and postnatal outcomes after intrauterine intervention.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herberg, Ulrike UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Geipel, Annegret UNSPECIFIED UNSPECIFIED UNSPECIFIED Gembruch, Ulrich UNSPECIFIED orcid.org/0000-0001-8284-4669 UNSPECIFIED Breuer, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-426508
DOI:	10.1017/S104795111400122X
Journal or Publication Title:	Cardiol. Young
Volume:	24
Page Range:	S. 47 - 55
Date:	2014
Publisher:	CAMBRIDGE UNIV PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1467-1107
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LEFT-HEART SYNDROME; RESTRICTIVE ATRIAL SEPTUM; AORTIC-STENOSIS; EXPERIENCE; INTACT; FETUSES; MANAGEMENT; MORPHOLOGY Multiple languages Cardiac & Cardiovascular Systems; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42650