Xicoy, Blanca ORCID: 0000-0002-0295-1307, Ribera, Josep-Maria, Mueller, Markus, Garcia, Olga, Hoffmann, Christian, Oriol, Albert ORCID: 0000-0001-6804-2221, Hentrich, Marcus, Grande, Carlos, Wasmuth, Jan-Christian, Esteve, Jordi, van Lunzen, Jan, del Potro, Eloy, Knechten, Heribert, Brunet, Salut, Mayr, Christoph, Escoda, Lourdes, Schommers, Philipp ORCID: 0000-0003-3375-6800, Alonso, Natalia, Vall-Llovera, Ferran, Perez, Montserrat, Morgades, Mireia ORCID: 0000-0003-0295-2534, Gonzalez, Jose, Fernandez, Angeles, Thoden, Jan, Goekbuget, Nicola, Hoelzer, Dieter, Faetkenheuer, Gerd and Wyen, Christoph (2014). Dose-intensive chemotherapy including rituximab is highly effective but toxic in human immunodeficiency virus-infected patients with Burkitt lymphoma/leukemia: parallel study of 81 patients. Leuk. Lymphoma, 55 (10). S. 2341 - 2349. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1029-2403

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Abstract

The results of intensive immunochemotherapy were analyzed in human immunodeficiency virus (HIV)-related Burkitt lymphoma/leukemia (BLL) in two cohorts (Spain and Germany). Alternating cycles of chemotherapy were administered, with dose reductions for patients over 55 years. Eighty percent of patients achieved remission, 11% died during induction, 9% failed and 7% died in remission. Four-year overall survival (OS) and progression-free survival (PFS) probabilities were 72% (95% confidence interval [CI]: 62-82%) and 71% (95% CI: 61-81%). CD4 T-cell count < 200/mu L and bone marrow involvement were associated with poor OS (hazard ratio [HR] 3.2 [1.2-8.3] and HR 2.7 [1.1-6.6]) and PFS (HR 3.5 [1.3-9.1] and HR 2.4 [1-5.7]), bone marrow involvement with poor disease-free survival (DFS) (HR 14.4 [1.7-119.7] and Eastern Cooperative Oncology Group (ECOG) score > 2 (odds ratio [OR] 11.9 [1.4-99.9]) with induction death. In HIV-related BLL, intensive immunochemotherapy was feasible and effective, but toxic. Prognostic factors were performance status, CD4 T-cell count and bone marrow involvement.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Xicoy, BlancaUNSPECIFIEDorcid.org/0000-0002-0295-1307UNSPECIFIED
Ribera, Josep-MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia, OlgaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffmann, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oriol, AlbertUNSPECIFIEDorcid.org/0000-0001-6804-2221UNSPECIFIED
Hentrich, MarcusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grande, CarlosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wasmuth, Jan-ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Esteve, JordiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Lunzen, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
del Potro, EloyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knechten, HeribertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brunet, SalutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mayr, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Escoda, LourdesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schommers, PhilippUNSPECIFIEDorcid.org/0000-0003-3375-6800UNSPECIFIED
Alonso, NataliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vall-Llovera, FerranUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perez, MontserratUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morgades, MireiaUNSPECIFIEDorcid.org/0000-0003-0295-2534UNSPECIFIED
Gonzalez, JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fernandez, AngelesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thoden, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goekbuget, NicolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoelzer, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faetkenheuer, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wyen, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-427276
DOI: 10.3109/10428194.2013.878933
Journal or Publication Title: Leuk. Lymphoma
Volume: 55
Number: 10
Page Range: S. 2341 - 2349
Date: 2014
Publisher: TAYLOR & FRANCIS LTD
Place of Publication: ABINGDON
ISSN: 1029-2403
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ACTIVE ANTIRETROVIRAL THERAPY; NON-HODGKINS-LYMPHOMA; B-CELL LYMPHOMA; PHASE-II TRIAL; INFUSIONAL CYCLOPHOSPHAMIDE; CODOX-M/IVAC; DOXORUBICIN; VINCRISTINE; ETOPOSIDE; PREDNISONEMultiple languages
Oncology; HematologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/42727

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