Universität zu Köln

Sigurbjoernsdottir, Sara, Mathew, Renjith and Leptin, Maria ORCID: 0000-0001-7097-348X (2014). Molecular mechanisms of de novo lumen formation. Nat. Rev. Mol. Cell Biol., 15 (10). S. 665 - 677. LONDON: NATURE PUBLISHING GROUP. ISSN 1471-0080

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Abstract

Many organs contain networks of epithelial tubes that transport gases or fluids. A lumen can be generated by tissue that enwraps a pre-existing extracellular space or it can arise de novo either between cells or within a single cell in a position where there was no space previously. Apparently distinct mechanisms of de novo lumen formation observed in vitro-in three-dimensional cultures of endothelial and Madin-Darby canine kidney (MDCK) cells-and in vivo-in zebrafish vasculature, Caenorhabditis elegans excretory cells and the Drosophila melanogaster trachea-in fact share many common features. In all systems, lumen formation involves the structured expansion of the apical plasma membrane through general mechanisms of vesicle transport and of microtubule and actin cytoskeleton regulation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sigurbjoernsdottir, Sara UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathew, Renjith UNSPECIFIED UNSPECIFIED UNSPECIFIED Leptin, Maria UNSPECIFIED orcid.org/0000-0001-7097-348X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-427517
DOI:	10.1038/nrm3871
Journal or Publication Title:	Nat. Rev. Mol. Cell Biol.
Volume:	15
Number:	10
Page Range:	S. 665 - 677
Date:	2014
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1471-0080
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language 3-DIMENSIONAL EXTRACELLULAR MATRICES; MITOTIC SPINDLE ORIENTATION; HEPATOCYTE GROWTH-FACTOR; APICAL MEMBRANE DOMAIN; TRACHEAL TUBE FUSION; EPITHELIAL MORPHOGENESIS; CELL-POLARITY; DROSOPHILA TRACHEA; CAPILLARY LUMEN; IN-VIVO Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/42751