Universität zu Köln

Lohr, Frank ORCID: 0000-0003-1014-5556, Georg, Dietmar ORCID: 0000-0002-8327-3877, Cozzi, Luca, Eich, Hans Theodor, Weber, Damien C., Koeck, Julia, Knausl, Barbara ORCID: 0000-0003-4031-1711, Dieckmann, Karin, Abo-Madyan, Yasser ORCID: 0000-0003-2205-503X, Fiandra, Christian, Mueller, Rolf-Peter, Engert, Andreas and Ricardi, Umberto (2014). Novel radiotherapy techniques for involved-field and involved-node treatment of mediastinal Hodgkin lymphoma When should they be considered and which questions remain open? Strahlenther. Onkol., 190 (10). S. 864 - 871. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-099X

Full text not available from this repository.

Abstract

Purpose. Hodgkin lymphoma (HL) is a highly curable disease. Reducing late complications and second malignancies has become increasingly important. Radiotherapy target paradigms are currently changing and radiotherapy techniques are evolving rapidly. Design. This overview reports to what extent target volume reduction in involved-node (IN) and advanced radiotherapy techniques, such as intensity-modulated radiotherapy (IMRT) and proton therapy-compared with involved-field (IF) and 3D radiotherapy (3D-RT)-can reduce high doses to organs at risk (OAR) and examines the issues that still remain open. Results. Although no comparison of all available techniques on identical patient datasets exists, clear patterns emerge. Advanced dose-calculation algorithms (e.g., convolution-superposition/Monte Carlo) should be used in mediastinal HL. INRT consistently reduces treated volumes when compared with IFRT with the exact amount depending on the INRT definition. The number of patients that might significantly benefit from highly conformal techniques such as IMRT over 3D-RT regarding high-dose exposure to organs at risk (OAR) is smaller with INRT. The impact of larger volumes treated with low doses in advanced techniques is unclear. The type of IMRT used (static/rotational) is of minor importance. All advanced photon techniques result in similar potential benefits and disadvantages, therefore only the degree-of-modulation should be chosen based on individual treatment goals. Treatment in deep inspiration breath hold is being evaluated. Protons theoretically provide both excellent high-dose conformality and reduced integral dose. Conclusion. Further reduction of treated volumes most effectively reduces OAR dose, most likely without disadvantages if the excellent control rates achieved currently are maintained. For both IFRT and INRT, the benefits of advanced radiotherapy techniques depend on the individual patient/target geometry. Their use should therefore be decided case by case with comparative treatment planning.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lohr, Frank UNSPECIFIED orcid.org/0000-0003-1014-5556 UNSPECIFIED Georg, Dietmar UNSPECIFIED orcid.org/0000-0002-8327-3877 UNSPECIFIED Cozzi, Luca UNSPECIFIED UNSPECIFIED UNSPECIFIED Eich, Hans Theodor UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Damien C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koeck, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Knausl, Barbara UNSPECIFIED orcid.org/0000-0003-4031-1711 UNSPECIFIED Dieckmann, Karin UNSPECIFIED UNSPECIFIED UNSPECIFIED Abo-Madyan, Yasser UNSPECIFIED orcid.org/0000-0003-2205-503X UNSPECIFIED Fiandra, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Rolf-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Engert, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Ricardi, Umberto UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-427533
DOI:	10.1007/s00066-014-0719-9
Journal or Publication Title:	Strahlenther. Onkol.
Volume:	190
Number:	10
Page Range:	S. 864 - 871
Date:	2014
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1439-099X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTENSITY-MODULATED RADIOTHERAPY; 3-DIMENSIONAL CONFORMAL RADIOTHERAPY; 2ND CANCER-RISKS; RADIATION-THERAPY; PROTON THERAPY; BREAST-CANCER; PROSTATE-CANCER; CORONARY-ARTERY; MEDICAL STAFF; DEGRO-QUIRO Multiple languages Oncology; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42753