Universität zu Köln

Diehl-Schmid, Janine ORCID: 0000-0002-7745-1382, Onur, Oezguer A., Kuhn, Jens, Gruppe, Traugott and Drzezga, Alexander (2014). Imaging Frontotemporal Lobar Degeneration. Curr. Neurol. Neurosci. Rep., 14 (10). NEW YORK: SPRINGER. ISSN 1534-6293

Full text not available from this repository.

Abstract

The term frontotemporal lobar degeneration (FTLD) refers to a group of neurodegenerative disorders that target the frontal and temporal lobes. It accounts for approximately 10 % of pathologically confirmed dementias but has been demonstrated to be as prevalent as Alzheimer's disease in patients below the age of 65. The 3 major clinical syndromes associated with FTLD include behavioral variant frontotemporal dementia, semantic and nonfluent variants of primary progressive aphasia. The more recently introduced term logopenic variant appears to represent an atypical form of Alzheimer's disease in the majority of cases. The neuropathology underlying these clinical syndromes is very heterogeneous and does not correlate well with the clinical phenotype. This causes great difficulties in early and reliable diagnosis and treatment of FTLD. However, significant advances have been made in recent years via the application of magnetic resonance imaging and positron emission tomography imaging methods as biomarkers. The current review aims to provide a synopsis on the value of magnetic resonance imaging-based and molecular imaging procedures in FTLD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Diehl-Schmid, Janine UNSPECIFIED orcid.org/0000-0002-7745-1382 UNSPECIFIED Onur, Oezguer A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruppe, Traugott UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-427701
DOI:	10.1007/s11910-014-0489-x
Journal or Publication Title:	Curr. Neurol. Neurosci. Rep.
Volume:	14
Number:	10
Date:	2014
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1534-6293
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PRIMARY-PROGRESSIVE-APHASIA; CEREBRAL GLUCOSE-METABOLISM; PITTSBURGH COMPOUND-B; MAGNETIC-RESONANCE-SPECTROSCOPY; POSITRON-EMISSION-TOMOGRAPHY; PHF-TAU RADIOLIGAND; ALZHEIMERS-DISEASE; BEHAVIORAL VARIANT; SEMANTIC DEMENTIA; NETWORK CONNECTIVITY Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42770