Universität zu Köln

Kohls, Gregor, Thoenessen, Heike, Bartley, Gregory K., Grossheinrich, Nicola, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Herpertz-Dahlmann, Beate and Konrad, Kerstin ORCID: 0000-0001-9039-2615 (2014). Differentiating neural reward responsiveness in autism versus ADHD. Dev. Cogn. Neurosci., 10. S. 104 - 117. OXFORD: ELSEVIER SCI LTD. ISSN 1878-9307

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Abstract

Although attention deficit hyperactivity disorders (ADHD) and autism spectrum disorders (ASD) share certain neurocognitive characteristics, it has been hypothesized to differentiate the two disorders based on their brain's reward responsiveness to either social or monetary reward. Thus, the present fMRI study investigated neural activation in response to both reward types in age and IQ-matched boys with ADHD versus ASD relative to typically controls (TDC). A significant group by reward type interaction effect emerged in the ventral striatum with greater activation to monetary versus social reward only in TDC, whereas subjects with ADHD responded equally strong to both reward types, and subjects with ASD showed low striatal reactivity across both reward conditions. Moreover, disorderspecific neural abnormalities were revealed, including medial prefrontal hyperactivation in response to social reward in ADHD versus ventral striatal hypoactivation in response to monetary reward in ASD. Shared dysfunction was characterized by fronto-striato-parietal hypoactivation in both clinical groups when money was at stake. Interestingly, lower neural activation within parietal circuitry was associated with higher autistic traits across the entire study sample. In sum, the present findings concur with the assumption that both ASD and ADHD display distinct and shared neural dysfunction in response to reward. (C) 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kohls, Gregor UNSPECIFIED UNSPECIFIED UNSPECIFIED Thoenessen, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Bartley, Gregory K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grossheinrich, Nicola UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Herpertz-Dahlmann, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED Konrad, Kerstin UNSPECIFIED orcid.org/0000-0001-9039-2615 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-427929
DOI:	10.1016/j.dcn.2014.08.003
Journal or Publication Title:	Dev. Cogn. Neurosci.
Volume:	10
Page Range:	S. 104 - 117
Date:	2014
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1878-9307
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; SPECTRUM DISORDERS; MONETARY REWARD; SOCIAL REWARD; SUSTAINED ATTENTION; RESPONSE-INHIBITION; CONDUCT DISORDER; HUMAN BRAIN; CHILDREN Multiple languages Psychology, Developmental; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42792