Universität zu Köln

Klein, Gilles, Burghaus, Lothar, Valliant, Michel, Pieri, Vannina, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Diederich, Nico (2014). Dysautonomia in Narcolepsy: Evidence by Questionnaire Assessment. J. Clin. Neurol., 10 (4). S. 314 - 320. SEOUL: KOREAN NEUROLOGICAL ASSOC. ISSN 2005-5013

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Abstract

Background and Purpose Excessive daytime sleepiness and sudden sleep attacks are the main features of narcolepsy, but rapid-eye-movement sleep behavior disorder (RED), hyposmia, and depression can also occur. The latter symptoms are nonmotor features in idiopathic Parkinson's disease (IPD). In the present study, IPD-proven diagnostic tools were tested to determine whether they are also applicable in the assessment of narcolepsy. Methods This was a case-control study comparing 15 patients with narcolepsy (PN) and 15 control subjects (CS) using the Scales for Outcomes in Parkinson's Autonomic Test (SCOPA-AUT), Parkinson's Disease Nonmotor Symptoms (PDNMS), University of Pennsylvania Smell Test, Farnsworth-Munsell 100 Hue test, Beck Depression Inventory, and the RBD screening questionnaire. Results Both the PN and CS exhibited mild hyposmia and no deficits in visual tests. Frequent dysautonomia in all domains except sexuality was found for the PN. The total SCOPA-AUT score was higher for the PN (18.47 +/- 10.08, mean SD) than for the CS (4.40 +/- 3.09), as was the PDNMS score (10.53 +/- 4.78 and 1.80 +/- 2.31, respectively). RBD was present in 87% of the PN and 0% of the CS. The PN were more depressed than the CS. The differences between the PN and CS for all of these variables were statistically significant (all p<0.05). Conclusions The results of this study provide evidence for the presence of dysautonomia and confirm the comorbidities of depression and RED in narcolepsy patients. The spectrum, which is comparable to the nonmotor complex in IPD, suggests wide-ranging, clinically detectable dysfunction beyond the narcoleptic core syndrome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Klein, Gilles UNSPECIFIED UNSPECIFIED UNSPECIFIED Burghaus, Lothar UNSPECIFIED UNSPECIFIED UNSPECIFIED Valliant, Michel UNSPECIFIED UNSPECIFIED UNSPECIFIED Pieri, Vannina UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Diederich, Nico UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-428119
DOI:	10.3988/jcn.2014.10.4.314
Journal or Publication Title:	J. Clin. Neurol.
Volume:	10
Number:	4
Page Range:	S. 314 - 320
Date:	2014
Publisher:	KOREAN NEUROLOGICAL ASSOC
Place of Publication:	SEOUL
ISSN:	2005-5013
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SLEEP BEHAVIOR DISORDER; PARKINSONS-DISEASE; NEURONS; BRAIN; CATAPLEXY; OREXINS; RATS Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42811